86215-36-3

86215-36-3 structure

Name: 1-(3,4-DICHLOROBENZYL)PIPERAZINE
Chemical Name: 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,hydrochloride
CAS Number: 86215-36-3
Molecular Formula: C₁₁H₁₂Cl₃N
Molecular Weight: 264.58
Catalog: Signaling Pathways Neuronal Signaling Dopamine Transporter
Create Date: 2018-12-17 16:06:26
Modify Date: 2024-01-02 20:51:14
DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].

Name	1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,hydrochloride
Synonyms	dov 216,303 hydrochloride

Description	DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
Target	14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT[2]
References	[1]. Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. [2]. Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. [3]. Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61.

66504-44-7

86215-36-3

Literature: Hagen, Eric J.; Halloran, Kevin Patent: US2007/43100 A1, 2007 ; Location in patent: Page/Page column 10-11 ;