Biphenylindanone A

Modify Date: 2024-01-14 12:38:30

Biphenylindanone A structure	Common Name	Biphenylindanone A
	CAS Number	866823-73-6	Molecular Weight	454.557
	Density	1.2±0.1 g/cm3	Boiling Point	676.9±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₃₀O₄	Melting Point	N/A
	MSDS	USA	Flash Point	225.8±25.0 °C

Use of Biphenylindanone A

Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders[1].

Name	4-[3-[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydroinden-5-yl)oxymethyl]phenyl]benzoic acid
Synonym	More Synonyms

Description	Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR2
In Vitro	Biphenylindanone A (BINA) shows activity on glutamate-induced scintillation proximity assay [3H]IP1 hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate[1].
References	[1]. Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site. J Pharmacol Exp Ther. 2008 Jul;326(1):240-51.

RIDADR	NONH for all modes of transport

LS-193,571

BINA

[1,1'-Biphenyl]-4-carboxylic acid, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-

3'-{[(2-Cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl}-4-biphenylcarboxylic acid

cc-230

Biphenylindanone A

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Price: ￥1300/1 mg

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