JUN-1111 structure
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Common Name | JUN-1111 | ||
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CAS Number | 874351-38-9 | Molecular Weight | 287.31400 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C15H17N3O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of JUN-1111JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1[1][2]. |
Name | 7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione |
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Synonym | More Synonyms |
Description | JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1[1][2]. |
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Related Catalog | |
Target |
IC50:0.38 µM (Cdc25A); 1.8 µM (Cdc25B); 0.66 µM (Cdc25C); 28 µM (VHR); 37 µM (PTP1B)[1] |
In Vitro | JUN-1111 (10, 30 µM; 17 h) 在 tsFT210 细胞中诱导细胞周期停滞在 G1 和 G2/M 期[1]。 JUN-1111 (10, 30 µM; 1 h) 以剂量依赖性方式降低 tsFT210 细胞中 phosphoCdk1 的表达[1]。 JUN-1111 (0-20 µM) 在哺乳动物细胞中诱导活性氧的形成[2]。 Cell Cycle Analysis[1] Cell Line: tsFT210 cells Concentration: 10, 30 µM Incubation Time: 17 h Result: Induced cell cycle arrest at G1 and G2/M phases. Western Blot Analysis[1] Cell Line: tsFT210 cells Concentration: 10, 30 µM Incubation Time: 1 h Result: Decreased the expression of phosphoCdk1 in a dose-dependent manner. |
References |
Molecular Formula | C15H17N3O3 |
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Molecular Weight | 287.31400 |
Exact Mass | 287.12700 |
PSA | 71.53000 |
LogP | 0.59510 |
jun-1111 |
unii-fm4058y01h |