Tiospirone

Modify Date: 2024-01-06 14:48:53

Tiospirone Structure
Tiospirone structure
 Common Name Tiospirone
CAS Number 87691-91-6 Molecular Weight 440.60100
Density 1.29g/cm3 Boiling Point 600.9ºC at 760 mmHg
Molecular Formula C24H32N4O2S Melting Point N/A
MSDS N/A Flash Point 317.2ºC

 Use of Tiospirone


Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].

 Names

Name 8-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione
Synonym More Synonyms

 Tiospirone Biological Activity

Description Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].
Related Catalog
References

[1]. Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68(1-2):93-8.  

[2]. Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81.  

 Chemical & Physical Properties

Density 1.29g/cm3
Boiling Point 600.9ºC at 760 mmHg
Molecular Formula C24H32N4O2S
Molecular Weight 440.60100
Flash Point 317.2ºC
Exact Mass 440.22500
PSA 84.99000
LogP 3.84870
Index of Refraction 1.652

 Synthetic Route

3,3-Tetramethyleneglutarimide structure

3,3-Tetramethyl...

CAS#:1075-89-4

8-(1,2-benzisothiazol-3-yl)-8-aza-5-azoniaspiro[4.5]decane bromide structure

8-(1,2-benzisot...

CAS#:87691-94-9

~89%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
3-(1-Piperazinyl)-1,2-benzisothiazole structure

3-(1-Piperaziny...

CAS#:87691-87-0

8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione structure

8-(4-Bromobutyl...

CAS#:80827-62-9

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Mead Johnson and Company Patent: US4411901 A1, 1983 ;
2-[(2-carbonochloridoylphenyl)disulfanyl]benzoyl chloride structure

2-[(2-carbonoch...

CAS#:19602-82-5

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
3-Chlor-1,2-benzisothiazol structure

3-Chlor-1,2-ben...

CAS#:7716-66-7

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
Benzisothiazolone structure

Benzisothiazolone

CAS#:2634-33-5

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
2,2′-dithiodibenzoic acid structure

2,2′-dithiodibe...

CAS#:119-80-2

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
Benzoyl chloride, 2-(chlorothio)- (9CI) structure

Benzoyl chlorid...

CAS#:3950-02-5

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
3-(1-Piperazinyl)-1,2-benzisothiazole structure

3-(1-Piperaziny...

CAS#:87691-87-0

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
8-(4-Chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione structure

8-(4-Chlorobuty...

CAS#:21098-11-3

3-(1-Piperazinyl)-1,2-benzisothiazole structure

3-(1-Piperaziny...

CAS#:87691-87-0

~%

Tiospirone Structure

Tiospirone

CAS#:87691-91-6

Literature: Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369

 Synonyms

Tiospirona [Spanish]
tiaspirone
Tiospirone [INN]
Tiospironum [Latin]
[14C]-Tiospirone
Tiospironum
Tiospirona
8-{4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl}-8-azaspiro[4.5]decane-7,9-dione
8-Azaspiro(4,5)decane-7,9-dione,8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)
TIOSPIRONE
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Chemsrc provides Tiospirone(CAS#:87691-91-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tiospirone are included as well.>> amp version: Tiospirone

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