Naxagolide

Modify Date: 2024-01-02 19:21:46

Naxagolide structure	Common Name	Naxagolide
	CAS Number	88058-88-2	Molecular Weight	247.333
	Density	1.1±0.1 g/cm3	Boiling Point	391.7±42.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₁NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	190.7±27.9 °C

Use of Naxagolide

Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2].

Name	(4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol
Synonym	More Synonyms

Description	Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor
In Vitro	在体外，Naxagolide ((+)-PHNO) 抑制大鼠纹状体膜上的 [3H]apomorphine (IC50 = 23 nM) 或 [3 H]spiperone (IC50 = 55 nM)[1]。
In Vivo	在小鼠中，Naxagolide ((+)-PHNO) 在单侧尾部切除的动物中产生体温过低 (13 μg/kg i.p.) 和姿势不对称 (4 μg/kg i.p.)[1]。在大鼠中，Naxagolide ((+)-PHNO) 在 6-羟基多巴胺损伤的动物中产生刻板印象（10 μg/kg i.p.）和对侧转向（5 μg/kg i.p.），持续 1 至 3 小时[1] 。
References	[1]. G E Martin, et al. Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]. J Pharmacol Exp Ther. 1984 Sep;230(3):569-76. [2]. E F Domino, et al. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265(3):1387-91.

Density	1.1±0.1 g/cm3
Boiling Point	391.7±42.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₁NO₂
Molecular Weight	247.333
Flash Point	190.7±27.9 °C
Exact Mass	247.157227
PSA	32.70000
LogP	2.55
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.553

HS Code	2934999090

Precursor 6
CAS#:88058-72-4 (4aR,10bR)-3,4,... CAS#:6836-19-7 7-Methoxy-1-tet... CAS#:22009-38-7 7-Hydroxy-1-tet... CAS#:32263-64-2 7-(BENZYLOXY)-3...
CAS#:2472-15-3 2-amino-7-benzy... CAS#:2451-66-3 trans-2-amino-7...
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(+)-PHNO

4-Propyl-9-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine

(+)-trans-1a,2,3,4a,5,6-Hexahydro-9-hydroxy-4-propyl-4H-naphth-[1,2-b]-1,4-oxazine

Naxagolida

dopazinol

(4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol

Naxagolide

(+)-4-Propyl-9-hydroxynaphthoxazine

2H-Naphth[1,2-b]-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, (4aR,10bR)-

(4aR)-trans-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol

PHNO

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Naxagolide free base
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Naxagolide
Price: $625.0/100mg $1250.0/250mg $2500.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Naxagolide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥3000/5 mg

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