HIF-2α-IN-4
Modify Date: 2024-01-26 20:54:49
HIF-2α-IN-4 structure
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Common Name | HIF-2α-IN-4 | ||
|---|---|---|---|---|
| CAS Number | 882268-69-1 | Molecular Weight | 287.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H9N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIF-2α-IN-4HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1]. |
| Name | HIF-2α-IN-4 |
|---|
| Description | HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1]. |
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| Related Catalog | |
| Target |
IC50: 5 μM (HIF-2α)[1] |
| In Vitro | HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1]. HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1]. |
| References |
| Molecular Formula | C9H9N3O4S2 |
|---|---|
| Molecular Weight | 287.32 |