Manidipine

Modify Date: 2024-01-02 12:56:50

Manidipine Structure
Manidipine structure
 Common Name Manidipine
CAS Number 89226-50-6 Molecular Weight 610.699
Density 1.2±0.1 g/cm3 Boiling Point 722.0±60.0 °C at 760 mmHg
Molecular Formula C35H38N4O6 Melting Point 125-128ºC
MSDS N/A Flash Point 390.4±32.9 °C

 Use of Manidipine


Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3].

 Names

Name 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonym More Synonyms

 Manidipine Biological Activity

Description Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3].
Related Catalog
References

[1]. Cheer, S.M. and K. McClellan, Manidipine: a review of its use in hypertension. Drugs, 2001. 61(12): p. 1777-99.

[2]. McKeage, K. and L.J. Scott, Manidipine: a review of its use in the management of hypertension. Drugs, 2004. 64(17): p. 1923-40.

[3]. Roca-Cusachs, A. and F. Triposkiadis, Antihypertensive effect of manidipine. Drugs, 2005. 65 Suppl 2: p. 11-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 722.0±60.0 °C at 760 mmHg
Melting Point 125-128ºC
Molecular Formula C35H38N4O6
Molecular Weight 610.699
Flash Point 390.4±32.9 °C
Exact Mass 610.279114
PSA 116.93000
LogP 5.46
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.601
Storage condition -20°C Freezer

 Safety Information

Hazard Codes Xi

 Synthetic Route

2-(4-benzhydrylpiperazin-1-yl)ethanol structure

2-(4-benzhydryl...

CAS#:10527-64-7

UNII:5DU0E310OI structure

UNII:5DU0E310OI

CAS#:74936-72-4

~%

Manidipine Structure

Manidipine

CAS#:89226-50-6

Literature: WO2011/23954 A2, ; Page/Page column 18 ;
3-Nitrobenzaldehyde structure

3-Nitrobenzaldehyde

CAS#:99-61-6

2-(4-benzhydrylpiperazin-1-yl)ethyl 3-oxobutanoate structure

2-(4-benzhydryl...

CAS#:89226-49-3

Methyl 3-aminocrotonate structure

Methyl 3-aminoc...

CAS#:14205-39-1

~77%

Manidipine Structure

Manidipine

CAS#:89226-50-6

Literature: Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
2-(4-benzhydrylpiperazin-1-yl)ethanol structure

2-(4-benzhydryl...

CAS#:10527-64-7

~%

Manidipine Structure

Manidipine

CAS#:89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797
N-Benzhydrylpiperazine structure

N-Benzhydrylpip...

CAS#:841-77-0

~%

Manidipine Structure

Manidipine

CAS#:89226-50-6

Literature: WO2011/23954 A2, ;
2-(4-benzhydrylpiperazin-1-yl)ethyl 3-oxobutanoate structure

2-(4-benzhydryl...

CAS#:89226-49-3

~%

Manidipine Structure

Manidipine

CAS#:89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797
2-(4-diphenylmethyl-1-piperazinyl)ethyl 2-(3-nitrobenzylidene)acetoacetate structure

2-(4-diphenylme...

CAS#:90120-00-6

Methyl 3-aminocrotonate structure

Methyl 3-aminoc...

CAS#:14205-39-1

~%

Manidipine Structure

Manidipine

CAS#:89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797

 Synonyms

2-[4-(Diphenylmethyl)-1-piperazinyl]ethylmethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate
2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester
1-diphenylmethyl-4-(2-hydroxyethyl)piperazine
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Manidipine 6300
Manidipine
UNII:6O4754US88
CV-4093,2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Manidipine (Manyper)
2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
(+/-)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester
2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Franidipine
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Manidipine suppliers

Price: $180/100mg

Reference only. check more Manidipine price

Related Compounds: More...
Manidipine
120092-68-4
Manidipine
126229-12-7
Manidipine-d4
1189656-59-4
(+)-manidipine
104196-68-1
(-)-Manidipine
133082-19-6
Manidipine 2HCl
89226-75-5
(S)-(+)-Manidipine
126451-47-6
dehydro-manidipine
104305-93-3
S-(+)-Manidipine-d4
1217836-12-8
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
Methyl 1-{4-[(dimethylamino)methyl]oxolan-3-yl}piperidine-3-carboxylate
2138392-38-6
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
3-Amino-3-(2-bromo-5-fluorophenyl)cyclobutan-1-ol
2229417-11-0
N-{1-[(2-methyl-1,3-thiazol-4-yl)methyl]piperidin-4-yl}cyclopropanecarboxamide
2770631-81-5
Chemsrc provides Manidipine(CAS#:89226-50-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Manidipine are included as well.>> amp version: Manidipine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved