3,4,5-Trimethoxycinnamic acid

Modify Date: 2024-01-02 09:39:39

3,4,5-Trimethoxycinnamic acid structure	Common Name	3,4,5-Trimethoxycinnamic acid
	CAS Number	90-50-6	Molecular Weight	238.237
	Density	1.2±0.1 g/cm3	Boiling Point	396.4±37.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₄O₅	Melting Point	125-127 °C(lit.)
	MSDS	Chinese USA	Flash Point	151.5±20.0 °C

Use of 3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

Name	3,4,5-trimethoxycinnamic acid
Synonym	More Synonyms

Description	3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Phenylpropanoids Research Areas >> Neurological Disease
Target	γ-subunit of GABAA receptor[2]
In Vitro	3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
In Vivo	3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1]. 3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].
References	[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9. [2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

Density	1.2±0.1 g/cm3
Boiling Point	396.4±37.0 °C at 760 mmHg
Melting Point	125-127 °C(lit.)
Molecular Formula	C₁₂H₁₄O₅
Molecular Weight	238.237
Flash Point	151.5±20.0 °C
Exact Mass	238.084122
PSA	64.99000
LogP	2.00
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.560

3,4,5-Trimethoxycinnamic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GE0722000

CHEMICAL NAME :: Cinnamic acid, 3,4,5-trimethoxy-

CAS REGISTRY NUMBER :: 90-50-6

BEILSTEIN REFERENCE NO. :: 1537834

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H14-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 422 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	GE0722000
HS Code	2916399090

Precursor 0
DownStream 6
CAS#:118-41-2 Trimethylgallic acid CAS#:25173-72-2 3-(3,4,5-Trimet... CAS#:7478-46-8 3,4-dimethyl-6-... CAS#:89813-62-7 2-(3,4,5-trimet...
CAS#:91562-22-0 5-(3-iodopropyl... CAS#:53560-26-2 3-(3,4,5-TRIMET...

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...

Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds.

Free Radic. Biol. Med. 38(6) , 763-72, (2005)

Phenolic compounds are not completely absorbed in the small intestine and so enter the colon, where they might exert physiological effects. To identify phenolics that are present in normal human colon...

[The detection of Azotobacter and its significance in criminal technical soil examinations].

Arch. Kriminol. 165(1-2) , 27-34, (1980)

3,4,5-Trimethoxycinnamic

o-methylsinapicacid

3,4,5-Trimethoxy cinnamic acid

(2E)-3-(3,4,5-Trimethoxyphenyl)acrylic acid

2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, (2E)-

3,4,5-Trimethoxycinnamic acid

2-propenoic acid, 3-(3,4,5-trimethoxyphenyl)-

TRIMETHOXYCINNAMICACID

3,4,5-trimethoxy-cinnamicaci

5-TriMethoxycinnaMic acid

3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

EINECS 201-999-8

3,4,5-Trimethoxyzimtsure

RARECHEM BK HC T328

MFCD00004388

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: ￥468.0/100g ￥158.0/25g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

3,4,5-Trimethoxycinnamic acid suppliers

Price: ￥40.2/5g

Reference only. check more 3,4,5-Trimethoxycinnamic acid price

3,4,5-Trimethoxycinnamic acid

Use of 3,4,5-Trimethoxycinnamic acid

Names