![]() GSK 5959 structure
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Common Name | GSK 5959 | ||
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CAS Number | 901245-65-6 | Molecular Weight | 394.467 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 527.3±50.0 °C at 760 mmHg | |
Molecular Formula | C22H26N4O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 272.7±30.1 °C |
Use of GSK 5959GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.IC50 value: 80 nMTarget: BRPF1in vitro: GSK-5959 inhibits BRPF1 interaction with histone H3. A cellular protein interaction assay measuring the displacement of NanoLuc-tagged BRPF1 bromodomain from Halotagged histone H3 is employed to demonstrate GSK-5959 is cell permeability and disruption of chromatin binding with IC50 of 0.98 μM. GSK-5959 is used at 10 μM final concentration in various in vitro assays. |
Name | N-[1,3-Dimethyl-2-oxo-6-(1-piperidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamide |
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Synonym | More Synonyms |
Description | GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.IC50 value: 80 nMTarget: BRPF1in vitro: GSK-5959 inhibits BRPF1 interaction with histone H3. A cellular protein interaction assay measuring the displacement of NanoLuc-tagged BRPF1 bromodomain from Halotagged histone H3 is employed to demonstrate GSK-5959 is cell permeability and disruption of chromatin binding with IC50 of 0.98 μM. GSK-5959 is used at 10 μM final concentration in various in vitro assays. |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 527.3±50.0 °C at 760 mmHg |
Molecular Formula | C22H26N4O3 |
Molecular Weight | 394.467 |
Flash Point | 272.7±30.1 °C |
Exact Mass | 394.200500 |
LogP | 2.35 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.636 |
Storage condition | 2-8℃ |
N-[1,3-Dimethyl-2-oxo-6-(1-piperidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamide |
Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy- |
GSK 5959 |
GSK-5959 |