Neocarzinostatin
Modify Date: 2024-01-06 15:24:39
Neocarzinostatin structure
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Common Name | Neocarzinostatin | ||
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| CAS Number | 9014-02-2 | Molecular Weight | 661.65200 | |
| Density | 1.52g/cm3 | Boiling Point | 900.5ºC at 760 mmHg | |
| Molecular Formula | C35H35NO12 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 498.4ºC | |
Use of NeocarzinostatinNeocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment [1][2]. |
| Name | Zinostatinum |
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| Description | Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment [1][2]. |
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| Related Catalog | |
| In Vitro | The EpCAM aptamer conjugated Neocarzinostatin (NCS) shows specificity to EpCAM-positive cells. The effects of the conjugates on cancer cells are impressive as the conjugate arrests the cell cycle and promoted apoptosis and necrosis. The high levels of PARP expression confirmed the DNA breaks upon conjugate treatment. NCS conjugated with EpCAM can be targeted to cancer cells sparing normal cells[3]. The IC50 values of Neocarzinostatin (72 hours) to C6 cells and U87MG cells were 493.64 nM, 462.96 nM, respectively[4]. In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3[5]. |
| References |
| Density | 1.52g/cm3 |
|---|---|
| Boiling Point | 900.5ºC at 760 mmHg |
| Molecular Formula | C35H35NO12 |
| Molecular Weight | 661.65200 |
| Flash Point | 498.4ºC |
| Exact Mass | 661.21600 |
| PSA | 174.77000 |
| LogP | 1.85820 |
| Index of Refraction | 1.688 |
| Personal Protective Equipment | Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US) |
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| RIDADR | NONH for all modes of transport |
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Neocarzinostatin-chromophore: a potent inhibitor of casein kinase II in vitro. Tanoue, S., et al.
Antibiotics 51 , 95-98, (1998)
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The enediyne antibiotics.
J. Med. Chem. 39 , 2103-2117, (1996)
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Reinvestigation of the proteolytic activity of neocarzinostatin.
J. Bacteriol. 182 , 1812-1818, (2000) Neocarzinostatin (NCS) is the most studied member of a family of chromoproteins secreted by a range of actinomycetes species. It has been proposed that in addition to their antitumoral activity relate... |