S-Me-DM1
Modify Date: 2024-01-02 12:21:36
S-Me-DM1 structure
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Common Name | S-Me-DM1 | ||
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| CAS Number | 912569-84-7 | Molecular Weight | 752.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H50ClN3O10S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of S-Me-DM1S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2]. |
| Name | S-methyl DM1 |
|---|
| Description | S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2]. |
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| Related Catalog | |
| Target |
Kd: 0.93 μM (Tubulin)[1] |
| In Vitro | S-methyl DM1 is the primary cellular or liver metabolite of antibody-maytansinoid conjugates prepared with thiol-containing maytansinoids DM1[1]. The half-maximal concentration for inhibition of microtubule assembly for for S-methyl DM1 is 4 μM. At 100 nM S-methyl-DM1 (84%) suppresses dynamic instability more strongly than Maytansine (45%). Tritiated S-methyl-DM1 bound to 37 high-affinity sites per microtubule (Kd of 0.1 μM)[1]. The concentration dependence curves for the inhibition of cell proliferation by S-methyl DM1 is sigmoidal in shape in MCF7 cells. Minimal inhibition occurred at 200 pM S-methyl DM1, and inhibition is maximal at 3 nM. S-methyl DM1 (IC50 of 330 pM) is slightly more potent than Maytansine (IC50 of 710 pM)[2]. S-methyl DM1 induces maxima of 80% accumulation of cells in G2/M as compared with only 30% in controls in MCF7 cells[2]. |
| References |
| Molecular Formula | C36H50ClN3O10S |
|---|---|
| Molecular Weight | 752.31 |