2-Chlorophenothiazine

Modify Date: 2024-01-02 14:52:15

2-Chlorophenothiazine structure	Common Name	2-Chlorophenothiazine
	CAS Number	92-39-7	Molecular Weight	233.717
	Density	1.3±0.1 g/cm3	Boiling Point	395.7±31.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₈ClNS	Melting Point	195-200 °C(lit.)
	MSDS	Chinese USA	Flash Point	193.1±24.8 °C
	Symbol	GHS07	Signal Word	Warning

Name	2-Chlorophenothiazine
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	395.7±31.0 °C at 760 mmHg
Melting Point	195-200 °C(lit.)
Molecular Formula	C₁₂H₈ClNS
Molecular Weight	233.717
Flash Point	193.1±24.8 °C
Exact Mass	233.006592
PSA	37.33000
LogP	5.18
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.680

2-Chlorophenothiazine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN7580000

CHEMICAL NAME :: Phenothiazine, 2-chloro-

CAS REGISTRY NUMBER :: 92-39-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H8-Cl-N-S

MOLECULAR WEIGHT :: 233.72

WISWESSER LINE NOTATION :: T C666 BM ISJ EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 160 mg/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 26,1205,1977

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	SN7580000
Hazard Class	6.1
HS Code	2934300000

Precursor 10
CAS#:583-55-1 1-Bromo-2-iodob... CAS#:1004-00-8 2-Amino-4-chlor... CAS#:108-94-1 Cyclohexanone CAS#:694-80-4 2-Bromochlorobenzene
CAS#:583-53-9 1,2-Dibromobenzene CAS#:615-41-8 1-Chloro-2-iodo... CAS#:105790-02-1 2-(2-bromo-phen... CAS#:101-17-7 3-Chlorodipheny...
CAS#:107522-19-0 acetic acid-[2-... CAS#:5182-81-0 2-chloro-10-eth...
DownStream 10
CAS#:108014-19-3 10-[2-methyl-3-... CAS#:38642-74-9 2-Cyano-phenoth... CAS#:3546-03-0 Cyamemazine CAS#:50-53-3 Chlorpromazine
CAS#:19607-03-5 2-chloro-10-met... CAS#:63615-79-2 10-Allyl-2-chlo... CAS#:1927-43-1 2-chloro-10H-ph... CAS#:92-84-2 Phenothiazine
CAS#:2095-17-2 didemethylchlor... CAS#:2002-32-6 Phenothiazin-3-...

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Reversing the Warburg effect as a treatment for glioblastoma.

J. Biol. Chem. 288(13) , 9153-64, (2013)

Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the War...

Broad specific enzyme-linked immunosorbent assay for determination of residual phenothiazine drugs in swine tissues.

Anal. Biochem. 454 , 7-13, (2014)

In this study, a novel generic hapten of phenothiazine drugs was synthesized by derivatization of 2-chlorophenothiazine with sodium bromoacetate. Then the hapten was coupled to bovine serum albumin fo...

N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

J. Med. Chem. 54 , 4247-63, (2011)

A total of 53 N-benzoylated phenoxazines and phenothiazines, including their S-oxidized analogues, were synthesized and evaluated for antiproliferative activity, interaction with tubulin, and cell cyc...

EINECS 202-152-5

10H-Phenothiazine, 2-chloro-

2-Chloro-10H-phenothiazine

MFCD00005016