Phenothiazine

Modify Date: 2024-01-01 20:53:39

Phenothiazine structure	Common Name	Phenothiazine
	CAS Number	92-84-2	Molecular Weight	199.272
	Density	1.2±0.1 g/cm3	Boiling Point	371.0±12.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₉NS	Melting Point	184 °C
	MSDS	Chinese USA	Flash Point	178.2±19.6 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of Phenothiazine

Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].

Name	10H-phenothiazine
Synonym	More Synonyms

Description	Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35. [2]. Ohlow MJ, et, al. Phenothiazine: the seven lives of pharmacology's first lead structure. Drug Discov Today. 2011 Feb;16(3-4):119-31.

Description

Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Neurological Disease

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35.

[2]. Ohlow MJ, et, al. Phenothiazine: the seven lives of pharmacology's first lead structure. Drug Discov Today. 2011 Feb;16(3-4):119-31.

Density	1.2±0.1 g/cm3
Boiling Point	371.0±12.0 °C at 760 mmHg
Melting Point	184 °C
Molecular Formula	C₁₂H₉NS
Molecular Weight	199.272
Flash Point	178.2±19.6 °C
Exact Mass	199.045563
PSA	37.33000
LogP	4.15
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.675
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
Water Solubility	2 mg/L (25 ºC)

Phenothiazine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN5075000

CHEMICAL NAME :: Phenothiazine

CAS REGISTRY NUMBER :: 92-84-2

BEILSTEIN REFERENCE NO. :: 0143237

LAST UPDATED :: 199712

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C12-H9-N-S

MOLECULAR WEIGHT :: 199.28

WISWESSER LINE NOTATION :: T C666 BM ISJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 425 mg/kg/5D

TOXIC EFFECTS :: Behavioral - headache Liver - jaundice, other or unclassified Blood - normocytic anemia

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 242,86,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

REFERENCE :: DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00586

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 66,888,1944 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

REFERENCE :: AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 6,160,1975 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,204,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENOTHIAZINE-air:10H TWA 5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84116 No. of Facilities: 175 (estimated) No. of Industries: 5 No. of Occupations: 15 No. of Employees: 5639 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84116 No. of Facilities: 5473 (estimated) No. of Industries: 54 No. of Occupations: 68 No. of Employees: 88048 (estimated) No. of Female Employees: 8791 (estimated)

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H317-H373-H412
Precautionary Statements	P273-P280
Target Organs	Blood
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant;N:Dangerousfortheenvironment;
Risk Phrases	R36/38;R43;R51/53
Safety Phrases	S26-S36-S61-S36/37/39-S29
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	SN5075000
HS Code	29343090

Precursor 10
CAS#:122-39-4 Diphenylamine CAS#:1286730-54-8 2-bromo-N-(2-io... CAS#:694-80-4 2-Bromochlorobenzene CAS#:137-07-5 2-Aminothiophenol
CAS#:583-55-1 1-Bromo-2-iodob... CAS#:108-94-1 Cyclohexanone CAS#:23451-95-8 2-Amino-5-bromo... CAS#:127-19-5 N,N-Dimethylace...
CAS#:38076-73-2 phenothiazin-10... CAS#:583-53-9 1,2-Dibromobenzene
DownStream 10
CAS#:5568-90-1 N,N-dimethyl-2-... CAS#:362-03-8 10H-Phenothiazi... CAS#:143399-31-9 10-hexadecylphe... CAS#:581-30-6 3-Phenothiazone
CAS#:1207-71-2 10H-Phenothiazi... CAS#:92-39-7 2-Chlorophenoth... CAS#:38076-63-0 1-Propanone,2-c... CAS#:1910-85-6 10H-Phenothiazi...
CAS#:20769-36-2 1-[10-[3-(Dimet... CAS#:182961-53-1 10-butylphenoth...

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

Altern. Lab. Anim. 43 , 101-27, (2015)

The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the hum...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Thiodiphenylamine

Dibenzothiazine

Phenosan

EINECS 202-196-5

Antiverm

Phenthiazine

Agrazine

PHENOTHIAZINE

Feeno

MFCD00005015

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phenothiazine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phenothiazine
Price: ￥198.0/500g ￥58.0/100g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Phenothiazine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phenothiazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Phenothiazine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

Phenothiazine suppliers

Price: ￥158/500g

Reference only. check more Phenothiazine price

Phenothiazine

Use of Phenothiazine

Names

Phenothiazine Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles55

Synonyms