Ajoene

Modify Date: 2024-01-08 19:56:31

Ajoene structure	Common Name	Ajoene
	CAS Number	92285-01-3	Molecular Weight	234.40200
	Density	1.181g/cm3	Boiling Point	376ºC at 760mmHg
	Molecular Formula	C₉H₁₄OS₃	Melting Point	N/A
	MSDS	N/A	Flash Point	181.2ºC

Use of Ajoene

Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2].

Name	Allyl[(2E)-3-(allyldisulfanyl)-2-propen-1-yl]sulfoniumolate
Synonym	More Synonyms

Description	Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Ajoene shows cytotoxicity with IC50s in the 7-41 uM range for B16/BL6, HT-29, A549, MDA-MB231, PANC-1, and SKBR-3 cells[1].
In Vivo	Ajoene (25 μg/g body weight of Ajoene in 100 mL Intralipid; i.p.; every other day from the day of inoculation up to day 28) inhibits both primary tumor growth[1]. Ajoene (25, 15 or 5 μg/g body weight of Ajoene in 100 μL Intralipid; i.p; every other day over 4 weeks) inhibits strongly metastasis to lung in the B16/BL6 melanoma tumor model in C57BL/6 mice[1].
References	[1]. Taylor P, et al. Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett. 2006;239(2):298-304. [2]. Ahmed N, et al. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res. 2001;21(5):3519-3523.

Density	1.181g/cm3
Boiling Point	376ºC at 760mmHg
Molecular Formula	C₉H₁₄OS₃
Molecular Weight	234.40200
Flash Point	181.2ºC
Exact Mass	234.02100
PSA	86.88000
LogP	3.86790
Index of Refraction	1.602

HS Code	2930909090

Allicin

CAS#:539-86-6

Ajoene

CAS#:92285-01-3

Literature: DANMARKS TEKNISKE UNIVERSITET; BJARNSHOLT, Thomas; HOEIBY, Niels; JENSEN, Peter OEstrup; PHIPPS, Richard; SHANMUGHAM, Meenakshi Sundaram; GENNIP, Maria van; CHRISTENSEN, Louise Dahl; JAKOBSEN, Tim Holm; TANNER, David; LARSEN, Thomas Ostenfeld; GIVSKOV, Michael Patent: WO2012/76016 A1, 2012 ; Location in patent: Page/Page column 18-19 ;

Diallyl disulfide

CAS#:2179-57-9

Ajoene

CAS#:92285-01-3

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(E,Z)-ajoene

2E,4Z-Heptadienal

(E/Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide

(E,Z)-2,4-heptadienal

4,5,9-trithiadodeca-1,6,11-triene-9-oxide

(Z,E)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide

(2E,4Z)-2,4-heptadienal

hepta-2t,4c-dienal

2,4-Heptadienal,(E,Z)

DC Chemicals Limited
China
Product Name: Ajoene
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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