LSD1 inhibitor-1
Modify Date: 2024-01-21 06:23:22
LSD1 inhibitor-1 structure
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Common Name | LSD1 inhibitor-1 | ||
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| CAS Number | 927019-63-4 | Molecular Weight | 328.500 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 467.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H36N8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 236.7±31.5 °C | |
Use of LSD1 inhibitor-1LSD1 inhibitor-1 is a bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 uM in vitro; significantly increases H3K4me1 and H3K4me2 dose-dependently from 0.25 uM to 10 uM, without affecting global H3K9me2 in HCT116 human colon carcinoma cells; induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5. |
| Name | 1,1'-[1,3-Propanediylbis(imino-3,1-propanediyl)]bis(2,3-dimethylguanidine) |
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| Synonym | More Synonyms |
| Description | LSD1 inhibitor-1 is a bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 uM in vitro; significantly increases H3K4me1 and H3K4me2 dose-dependently from 0.25 uM to 10 uM, without affecting global H3K9me2 in HCT116 human colon carcinoma cells; induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5. |
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| References | References 1. Sharma SK, et al. J Med Chem. 2010 Jul 22;53(14):5197-212. 2. Huang Y, et al. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8023-8. 3. Bi X, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3229-32. View Related Products by Target Histone Demethylase |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 467.7±55.0 °C at 760 mmHg |
| Molecular Formula | C15H36N8 |
| Molecular Weight | 328.500 |
| Flash Point | 236.7±31.5 °C |
| Exact Mass | 328.306305 |
| LogP | -0.57 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.531 |
| 1,1'-[1,3-Propanediylbis(imino-3,1-propanediyl)]bis(2,3-dimethylguanidine) |
| Guanidine, N,N'''-[1,3-propanediylbis(imino-3,1-propanediyl)]bis[N',N''-dimethyl- |