AS 1892802

Modify Date: 2024-09-25 18:32:41

AS 1892802 Structure
AS 1892802 structure
Common Name AS 1892802
CAS Number 928320-12-1 Molecular Weight 333.38400
Density 1.256±0.06 g/cm3 (20 °C, 760 mmHg) Boiling Point 531.2±50.0 °C (760 mmHg)
Molecular Formula C20H19N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AS 1892802


AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain[1].

 Names

Name Urea, N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]

 AS 1892802 Biological Activity

Description AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain[1].
Related Catalog
References

[1]. Yoshimi E, et al. Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J Pharmacol Exp Ther. 2010;334(3):955-963.

 Chemical & Physical Properties

Density 1.256±0.06 g/cm3 (20 °C, 760 mmHg)
Boiling Point 531.2±50.0 °C (760 mmHg)
Molecular Formula C20H19N3O2
Molecular Weight 333.38400
Exact Mass 333.14800
PSA 74.25000
LogP 4.06760