AZD 1678

Modify Date: 2024-04-05 22:17:33

AZD 1678 Structure
AZD 1678 structure
Common Name AZD 1678
CAS Number 942137-41-9 Molecular Weight 352.169
Density 1.6±0.1 g/cm3 Boiling Point 469.8±55.0 °C at 760 mmHg
Molecular Formula C11H8Cl2FN3O3S Melting Point N/A
MSDS N/A Flash Point 237.9±31.5 °C

 Use of AZD 1678


AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4; shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM); inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8. Asthma Phase 1 Clinical

 Names

Name 2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide
Synonym More Synonyms

 AZD 1678 Biological Activity

Description AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4; shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM); inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8. Asthma Phase 1 Clinical
References References 1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. View Related Products by Target Chemokine Receptor (CCR and CXCR) Asthma

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 469.8±55.0 °C at 760 mmHg
Molecular Formula C11H8Cl2FN3O3S
Molecular Weight 352.169
Flash Point 237.9±31.5 °C
Exact Mass 350.964752
LogP 3.86
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.614

 Synonyms

2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide
MFCD28975034
Benzenesulfonamide, 2,3-dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)-
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