PI 828
Modify Date: 2024-01-02 23:52:20
PI 828 structure
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Common Name | PI 828 | ||
|---|---|---|---|---|
| CAS Number | 942289-87-4 | Molecular Weight | 322.35800 | |
| Density | 1.316g/cm3 | Boiling Point | 534.2ºC at 760 mmHg | |
| Molecular Formula | C19H18N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 276.9ºC | |
Use of PI 828PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1]. |
| Name | 8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1]. |
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| Related Catalog | |
| Target |
p110α:173 nM (IC50) CK2:149 nM (IC50) CK2α2:1.127 μM (IC50) |
| In Vitro | PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells[2]. PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis[3]. Cell Viability Assay[2] Cell Line: 4T1 breast cancer cells and 4306 ovarian cancer cells Concentration: 0.01, 0.1, 1, 10 and 100 μM Incubation Time: Result: Exhibited cytotoxic effect. Apoptosis Analysis[3] Cell Line: Human embryonic carcinoma NCCIT cells Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM Incubation Time: 48 hours Result: Concentrations of ranging from 0.78 to 3.12 µM decreased caspase 3 activation; higher concentrations caused apoptosis. |
| References |
| Density | 1.316g/cm3 |
|---|---|
| Boiling Point | 534.2ºC at 760 mmHg |
| Molecular Formula | C19H18N2O3 |
| Molecular Weight | 322.35800 |
| Flash Point | 276.9ºC |
| Exact Mass | 322.13200 |
| PSA | 68.70000 |
| LogP | 3.52500 |
| Index of Refraction | 1.658 |
| HMS3229H13 |
| W-84 dibromide |
| HMS3266C12 |