ACA-28

Modify Date: 2024-07-17 10:21:03

ACA-28 structure	Common Name	ACA-28
	CAS Number	948044-25-5	Molecular Weight	316.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₆O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ACA-28

ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivationACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively[1].

Name	ACA-28

Description	ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivationACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Satoh R, et al. Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28. Bioorg Chem. 2020 Oct;103:104137.

Molecular Formula	C₁₇H₁₆O₆
Molecular Weight	316.31

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ACA-28
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Purity: 99.0%
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