3-BrB-PP1

Modify Date: 2024-01-10 09:16:52

3-BrB-PP1 structure	Common Name	3-BrB-PP1
	CAS Number	956025-99-3	Molecular Weight	360.25200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₈BrN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3-BrB-PP1

3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket)[1][2].

Name	3-[(3-bromophenyl)methyl]-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
Synonym	More Synonyms

Description	3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26(6):1654-1667.e7. [2]. Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26(21):2921-2928.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26(6):1654-1667.e7.

[2]. Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26(21):2921-2928.

Molecular Formula	C₁₆H₁₈BrN₅
Molecular Weight	360.25200
Exact Mass	359.07500
PSA	69.62000
LogP	4.09800

3-Bromophenylac...

CAS#:1878-67-7

3-BrB-PP1

CAS#:956025-99-3

Literature: Lourido, Sebastian; Zhang, Chao; Lopez, Michael S.; Tang, Keliang; Barks, Jennifer; Wang, Qiuling; Wildman, Scott A.; Shokat, Kevan M.; Sibley, L. David Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3068 - 3077