Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3BrB-PP1
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

956025-99-3

956025-99-3 structure

Name: 3-BrB-PP1
Chemical Name: 3-[(3-bromophenyl)methyl]-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
CAS Number: 956025-99-3
Molecular Formula: C₁₆H₁₈BrN₅
Molecular Weight: 360.25200
Catalog: Research Areas Cancer
Create Date: 2017-09-15 18:36:24
Modify Date: 2024-01-10 09:16:52
3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket)[1][2].

Name	3-[(3-bromophenyl)methyl]-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
Synonyms	3-[(3-Bromophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine 3-BrB-PP1

Description	3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26(6):1654-1667.e7. [2]. Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26(21):2921-2928.

Molecular Formula	C₁₆H₁₈BrN₅
Molecular Weight	360.25200
Exact Mass	359.07500
PSA	69.62000
LogP	4.09800

1878-67-7

956025-99-3

Literature: Lourido, Sebastian; Zhang, Chao; Lopez, Michael S.; Tang, Keliang; Barks, Jennifer; Wang, Qiuling; Wildman, Scott A.; Shokat, Kevan M.; Sibley, L. David Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3068 - 3077

98288-51-8

956025-99-3

1428640-42-9

77287-34-4

956025-99-3

Literature: Chapman, Eli; Farr, George W.; Furtak, Krystyna; Horwich, Arthur L. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 811 - 813

1364226-31-2

956025-99-3

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