L-Homopropargylglycine

Modify Date: 2024-01-02 18:00:51

L-Homopropargylglycine Structure
L-Homopropargylglycine structure
Common Name L-Homopropargylglycine
CAS Number 98891-36-2 Molecular Weight 127.14100
Density N/A Boiling Point N/A
Molecular Formula C6H9NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L-Homopropargylglycine


L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (S)-2-Aminohex-5-ynoic acid
Synonym More Synonyms

 L-Homopropargylglycine Biological Activity

Description L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C6H9NO2
Molecular Weight 127.14100
Exact Mass 127.06300
PSA 63.32000
LogP 0.51200

 Safety Information

HS Code 2922499990

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Synonyms

homoproparglyglycine
L-HOMOPROPARGYLGLYCINE
L-homopropargylglycine
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