24-Norursodeoxycholic acid

Modify Date: 2024-01-02 16:43:13

24-Norursodeoxycholic acid Structure
24-Norursodeoxycholic acid structure
Common Name 24-Norursodeoxycholic acid
CAS Number 99697-24-2 Molecular Weight 378.54500
Density 1.142±0.06 g/cm3 (20 °C, 760 mmHg) Boiling Point 536.7±25.0 °C (760 mmHg)
Molecular Formula C23H38O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 24-Norursodeoxycholic acid


24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.

 Names

Name 24-Norcholan-23-oic acid, 3,7-dihydroxy-, (3α,5β,7β)
Synonym More Synonyms

 24-Norursodeoxycholic acid Biological Activity

Description 24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.
Related Catalog
In Vitro 24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels[1].
References

[1]. Fickert P, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb;130(2):465-81.

 Chemical & Physical Properties

Density 1.142±0.06 g/cm3 (20 °C, 760 mmHg)
Boiling Point 536.7±25.0 °C (760 mmHg)
Molecular Formula C23H38O4
Molecular Weight 378.54500
Exact Mass 378.27700
PSA 77.76000
LogP 4.08780
Storage condition 2-8℃

 Synonyms

24-norursodeoxycholic acid
3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic acid
Norursodeoxycholic acid
24-Norursodeoxycholic acid
24-Nor Ursodeoxycholic Acid
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