Rimonabant-d10 hydrochloride

Modify Date: 2024-02-01 00:19:58

Rimonabant-d10 hydrochloride structure	Common Name	Rimonabant-d10 hydrochloride
	CAS Number	1044909-61-6	Molecular Weight	510.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₂D₁₀Cl₄N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Rimonabant-d10 hydrochloride

Rimonabant-d10 (SR 141716A-d10) hydrochloride is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].

Name	Rimonabant-d10 hydrochloride

Description	Rimonabant-d10 (SR 141716A-d10) hydrochloride is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):905-15. [3]. Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13. [4]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268. [5]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.

Molecular Formula	C₂₂H₁₂D₁₀Cl₄N₄O
Molecular Weight	510.31

Rimonabant-d10 hydrochloride

Use of Rimonabant-d10 hydrochloride

Names

Rimonabant-d10 hydrochloride Biological Activity

Chemical & Physical Properties