Bendamustine-d8 hydrochloride

Modify Date: 2024-01-16 10:24:39

Bendamustine-d8 hydrochloride structure	Common Name	Bendamustine-d8 hydrochloride
	CAS Number	1185068-23-8	Molecular Weight	402.77
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₄D₈Cl₃N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Bendamustine-d8 hydrochloride

Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

Name	Bendamustine-d8 hydrochloride

Description	Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. [3]. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. [4]. Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91.

Molecular Formula	C₁₆H₁₄D₈Cl₃N₃O₂
Molecular Weight	402.77

Bendamustine-d8 hydrochloride

Use of Bendamustine-d8 hydrochloride

Names

Bendamustine-d8 hydrochloride Biological Activity

Chemical & Physical Properties