KIF18A-IN-4 structure
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Common Name | KIF18A-IN-4 | ||
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CAS Number | 1197522-21-6 | Molecular Weight | 413.53 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C22H27N3O3S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of KIF18A-IN-4KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1]. |
Name | KIF18A-IN-4 |
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Description | KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1]. |
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Related Catalog | |
Target |
IC50: 6.16 μM (KIF18A)[1] |
In Vitro | KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+)[1]. KIF18A-IN-4 (0-10 μM; overnight) has an EC50 of 6.35 μM in OVCAR-3 cells by the mitotic index assay[1]. |
References |
Molecular Formula | C22H27N3O3S |
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Molecular Weight | 413.53 |