KIF18A-IN-4

Modify Date: 2024-01-09 16:37:45

KIF18A-IN-4 Structure
KIF18A-IN-4 structure
Common Name KIF18A-IN-4
CAS Number 1197522-21-6 Molecular Weight 413.53
Density N/A Boiling Point N/A
Molecular Formula C22H27N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KIF18A-IN-4


KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1].

 Names

Name KIF18A-IN-4

 KIF18A-IN-4 Biological Activity

Description KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1].
Related Catalog
Target

IC50: 6.16 μM (KIF18A)[1]

In Vitro KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+)[1]. KIF18A-IN-4 (0-10 μM; overnight) has an EC50 of 6.35 μM in OVCAR-3 cells by the mitotic index assay[1].
References

[1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.

 Chemical & Physical Properties

Molecular Formula C22H27N3O3S
Molecular Weight 413.53