Doxofylline-d4

Modify Date: 2024-01-11 00:54:43

Doxofylline-d4 structure	Common Name	Doxofylline-d4
	CAS Number	1346599-13-0	Molecular Weight	270.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₀D₄N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Doxofylline-d4

Doxofylline-d4 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV[1][2].

Name	Doxofylline-d4

Description	Doxofylline-d4 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.

Molecular Formula	C₁₁H₁₀D₄N₄O₄
Molecular Weight	270.28