iocetamic acid (200 mg)

Modify Date: 2024-01-10 11:43:49

iocetamic acid (200 mg) Structure
iocetamic acid (200 mg) structure
Common Name iocetamic acid (200 mg)
CAS Number 16034-77-8 Molecular Weight 613.95700
Density 2.416g/cm3 Boiling Point 658.2ºC at 760 mmHg
Molecular Formula C12H13I3N2O3 Melting Point 224-225ºC
MSDS N/A Flash Point 351.9ºC

 Use of iocetamic acid (200 mg)


Cholebrine (DRC 1201), a diagnostic aid, is an orally active chotecystographic contrast agent[1].

 Names

Name 3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid
Synonym More Synonyms

 iocetamic acid (200 mg) Biological Activity

Description Cholebrine (DRC 1201), a diagnostic aid, is an orally active chotecystographic contrast agent[1].
Related Catalog
In Vivo Cholebrine 在大鼠中 LD50 为 7 g/kg (口服) 和 0.7 g/kg (静脉注射)[2].
References

[1]. Owen JP, et al. Comparative study of iocetamic acid and calcium ipodate in the visualisation of the gallbladder and common bile duct. Clin Radiol. 1978 Sep;29(5):535-40.  

[2]. Janbroers JM, et al. Toxicologic studies of iocetamic acid in rats and dogs. Toxicol Appl Pharmacol. 1969 Mar;14(2):242-8.  

 Chemical & Physical Properties

Density 2.416g/cm3
Boiling Point 658.2ºC at 760 mmHg
Melting Point 224-225ºC
Molecular Formula C12H13I3N2O3
Molecular Weight 613.95700
Flash Point 351.9ºC
Exact Mass 613.80600
PSA 83.63000
LogP 3.73740
Vapour Pressure 3.21E-18mmHg at 25°C
Index of Refraction 1.75

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE6050000
CHEMICAL NAME :
Propionic acid, 3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methy l-
CAS REGISTRY NUMBER :
16034-77-8
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H13-I3-N2-O3
MOLECULAR WEIGHT :
613.97
WISWESSER LINE NOTATION :
ZR BI DI FI CNV1&1Y1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,997,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6131 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 260 (estimated) No. of Female Employees: 140 (estimated)

 Safety Information

HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Cholimil
DRC 1201
Acide iocetamique [INN-French]
N-(3-amino-2,4,6-triiodophenyl)-3-acetamido-2-methyl-propionic acid
Colebrina
IOCETAMIC ACID
Acidum jocetamicum
Iocetamsaeure
Acidum iocetamicum [INN-Latin]
Cholebrine
Acido iocetamico [INN-Spanish]