IDH1 Inhibitor 5

Modify Date: 2024-01-12 19:08:36

IDH1 Inhibitor 5 structure	Common Name	IDH1 Inhibitor 5
	CAS Number	1940128-37-9	Molecular Weight	450.57
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₄N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IDH1 Inhibitor 5

IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively[1].

Name	IDH1 Inhibitor 5

Description	IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)
Target	IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)[1]
In Vitro	IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein Concentration: 0-10 μM Incubation Time: 1 hour Result: Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.
References	[1]. Huang C, et al. Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors. ACS Med Chem Lett. 2022 Mar 28;13(4):734-741.

Molecular Formula	C₂₆H₃₄N₄O₃
Molecular Weight	450.57

IDH1 Inhibitor 5

Use of IDH1 Inhibitor 5

Names

IDH1 Inhibitor 5 Biological Activity

Chemical & Physical Properties