Topoisomerase II inhibitor 9

Modify Date: 2024-01-18 09:32:35

Topoisomerase II inhibitor 9 structure	Common Name	Topoisomerase II inhibitor 9
	CAS Number	2413901-61-6	Molecular Weight	491.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₇N₇O₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Topoisomerase II inhibitor 9

Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].

Name	Topoisomerase II inhibitor 9

Description	Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II:0.97 μM (IC50)
In Vitro	Topoisomerase II inhibitor 9 (Compound 19b) shows antiproliferative activity with IC50 values of 0.50 ± 0.1, 0.75 ± 0.1 and 2.91 ± 0.1 μM against Hep G‐2, Hep‐2 and Caco‐2 cells, respectively[1].
References	[1]. Eissa IH, et al. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors. Arch Pharm (Weinheim). 2019 Nov;352(11):e1900123.

Molecular Formula	C₂₂H₁₇N₇O₃S₂
Molecular Weight	491.55

Topoisomerase II inhibitor 9

Use of Topoisomerase II inhibitor 9

Names

Topoisomerase II inhibitor 9 Biological Activity

Chemical & Physical Properties