PDE5-IN-3

Modify Date: 2024-01-05 19:53:49

PDE5-IN-3 structure	Common Name	PDE5-IN-3
	CAS Number	2538149-57-2	Molecular Weight	448.27
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₄BrN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PDE5-IN-3

PDE5-IN-3 (compound 11j) is a potent PDE5 inhibitor with an IC50 of 1.57 nM. PDE5-IN-3 shows moderate EGFR inhibition with IC50 of 5.827 µM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC50=1286.96 ng/mL). PDE5-IN-3 induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity[1].

Name	PDE5-IN-3

Description	PDE5-IN-3 (compound 11j) is a potent PDE5 inhibitor with an IC50 of 1.57 nM. PDE5-IN-3 shows moderate EGFR inhibition with IC50 of 5.827 µM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC50=1286.96 ng/mL). PDE5-IN-3 induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	PDE5:1.57 nM (IC50) EGFR:5.827 μM (IC50)
In Vitro	PDE5-IN-3 lowers the expression levels of the anti-apoptotic Bcl-2 protein, and causes the high expression of the pro-apoptotic protein Bax, p53, cytochrome c and up-regulates active caspase-9 and caspase-3 levels[1].
References	[1]. Tarek S Ibrahim, et al. Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy. Bioorg Chem. 2020 Dec;105:104352.

Molecular Formula	C₂₁H₁₄BrN₅O₂
Molecular Weight	448.27

PDE5-IN-3

Use of PDE5-IN-3

Names

PDE5-IN-3 Biological Activity

Chemical & Physical Properties