hiCE inhibitor-1

Modify Date: 2024-01-13 16:29:25

hiCE inhibitor-1 structure	Common Name	hiCE inhibitor-1
	CAS Number	2654-68-4	Molecular Weight	457.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄Cl₂N₂O₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of hiCE inhibitor-1

hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].

Name	hiCE inhibitor-1

Description	hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43.

Molecular Formula	C₁₈H₁₄Cl₂N₂O₄S₂
Molecular Weight	457.35