MK-4965

Modify Date: 2024-01-03 15:52:34

MK-4965 structure	Common Name	MK-4965
	CAS Number	920035-77-4	Molecular Weight	426.26
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₃Cl₂N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK-4965

MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection[1].

Name	3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chloroph enoxy}-5-chlorobenzonitrile

Description	MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)[1]
References	[1]. Lai MT, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31.

Molecular Formula	C₂₀H₁₃Cl₂N₅O₂
Molecular Weight	426.26
Exact Mass	425.04500
PSA	110.57000
LogP	5.01998

MK-4965

Use of MK-4965

Names

MK-4965 Biological Activity

Chemical & Physical Properties