Pilocarpine-d3 hydrochloride

• 常用名: Pilocarpine-d3 hydrochloride
• 英文名: Pilocarpine-d3 hydrochloride
• CAS号: 1217838-88-4
• 分子量: 247.74
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₄D₃ClN₂O₂
• 熔点: N/A
• 闪点: N/A

Pilocarpine-d3 hydrochloride用途

匹罗卡品-d3(盐酸盐)是氘标记的匹罗卡品(盐酸盐)。盐酸毛果芸香碱是一种有效的M3型毒蕈碱乙酰胆碱受体(M3毒蕈碱受体)激动剂。

Pilocarpine-d3 hydrochloride名称

• 英文名: Pilocarpine-d3 hydrochloride

Pilocarpine-d3 hydrochloride生物活性

• 描述: 匹罗卡品-d3(盐酸盐)是氘标记的匹罗卡品(盐酸盐)。盐酸毛果芸香碱是一种有效的M3型毒蕈碱乙酰胆碱受体(M3毒蕈碱受体)激动剂。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.

  [3]. Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32.

  [4]. Wang RF, et al. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res. 2018 Mar 9;142:45-52.

  [5]. Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11.

Pilocarpine-d3 hydrochloride物理化学性质

• 分子式: C₁₁H₁₄D₃ClN₂O₂
• 分子量: 247.74