环吡酮胺
环吡酮胺结构式
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常用名 | 环吡酮胺 | 英文名 | Ciclopirox Olamine |
|---|---|---|---|---|
| CAS号 | 41621-49-2 | 分子量 | 268.352 | |
| 密度 | N/A | 沸点 | 350ºC at 760 mmHg | |
| 分子式 | C14H24N2O3 | 熔点 | 144ºC | |
| MSDS | 中文版 美版 | 闪点 | 165.5ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.
Mol. Pharm. 11(7) , 1991-6, (2014) Onychomycosis is a fungal infection mostly induced by dermatophytes such as Trichophyton rubrum. Due to slow nail growth, the treatment takes 3-9 months depending on the nail size and infected area. Hence, high efficacy of the active ingredient without system... |
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Development of ciclopirox olamine topical formulations: evaluation of drug release, penetration and cutaneous retention.
Pharm. Dev. Technol. 20(2) , 197-203, (2015) With the aim of reducing system absorption and consequently, the side effects, and simultaneously select a penetration enhancing, three topical formulations with 0.5% ciclopirox olamine (CO) and 15% of propylene glycol (PG), ethoxydiglycol or oleic acid were ... |
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The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment.
Antimicrob. Agents Chemother. 58(7) , 3837-42, (2014) Onychomycosis is a common fungal nail disease that is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. Keratin affinity of topical drugs is an important physicochemical property impacting therape... |
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Thermogelling hydrogels of cyclodextrin/poloxamer polypseudorotaxanes as aqueous-based nail lacquers: application to the delivery of triamcinolone acetonide and ciclopirox olamine.
Eur. J. Pharm. Biopharm. 83(3) , 370-7, (2013) This work investigated the use of in situ gelling hydrogels based on polypseudorotaxanes of Pluronic F-127 and partially methylated β-cyclodextrin as aqueous nail lacquers. N-acetylcysteine and urea were incorporated as penetration enhancers. The formulations... |
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Comparison of visual assessments versus planimetry assessments in a large-scale clinical trial of onychomycosis.
J. Dermatolog. Treat. 25(3) , 256-9, (2014) Computerized nail planimetry is an objective means of accurately assessing affected nail areas, versus the standard visual estimation method. However, no published comparison of visual assessment with planimetry is currently available on onychomycosis to supp... |
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Competitive displacement of drugs from cyclodextrin inclusion complex by polypseudorotaxane formation with poloxamer: implications in drug solubilization and delivery.
Eur. J. Pharm. Biopharm. 80(3) , 585-95, (2012) The competitive interactions between the poly-[propylene oxide] (POO)-poly-[ethylene oxide] (PEO) block copolymer poloxamer 407 (Pluronic F127) and two drugs, triamcinolone acetonide and ciclopirox olamine, by the formation of inclusion complexes with two cyc... |
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Ciclopirox olamine: a hydroxypyridone antifungal agent.
Clin. Dermatol. 9(4) , 471-7, (1991)
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Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.
Am. J. Physiol. Cell Physiol. 301(4) , C872-85, (2011) The F508del mutation, the most frequent in cystic fibrosis (CF), impairs the maturation of the CFTR chloride channel. The F508del defect can be partially overcome at low temperature (27°C) or with pharmacological correctors. However, the efficacy of corrector... |
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Hydration of nail plate: a novel screening model for transungual drug permeation enhancers.
Int. J. Pharm. 436(1-2) , 179-82, (2012) Drug delivery by topical route for the treatment of onychomycosis, a nail fungal infection, is challenging due to the unique barrier properties of the nail plate which imparts high resistance to the passage of antifungal drugs. Permeation enhancers are used i... |
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Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
Exp. Hematol. 41(9) , 799-807.e4, (2013) Ciclopirox, an antifungal agent commonly used for the dermatologic treatment of mycoses, has been shown recently to have antitumor properties. Although the exact mechanism of ciclopirox is unclear, its antitumor activity has been attributed to iron chelation ... |