溴匹立明
溴匹立明结构式
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常用名 | 溴匹立明 | 英文名 | Bropirimine |
|---|---|---|---|---|
| CAS号 | 56741-95-8 | 分子量 | 266.094 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | 473.2±55.0 °C at 760 mmHg | |
| 分子式 | C10H8BrN3O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 240.0±31.5 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
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CMV specific cytokine release assay in whole blood is optimized by combining synthetic CMV peptides and toll like receptor agonists.
J. Immunol. Methods 414 , 82-90, (2014) Interferon gamma release assays (IGRAs) are widely used to detect pathogen specific cellular immunity. Cytomegalovirus (CMV) is the foremost problematic viral infection in immunocompromised patients such as transplant or HIV infected patients. CMV antibody EL... |
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Bropirimine, an orally active anticancer agent for superficial bladder cancer.
Eur. Urol. 34(2) , 107-10, (1998) To investigate efficacy and safety of bropirimine, a new orally active interferon inducer, in patients with superficial bladder cancer.Twenty patients with histologically confirmed recurrent superficial transitional cell carcinoma (Ta or T1) were studied. At ... |
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Current and new strategies in immunotherapy for superficial bladder cancer.
Urology 64(3) , 409-21, (2004)
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Paclitaxel, bropirimine and linomide: effect on growth inhibition in a murine prostate cancer model by different growth regulatory mechanisms.
Methods Find. Exp. Clin. Pharmacol. 20(2) , 111-4, (1998) Paclitaxel, bropirimine and linomide therapy was evaluated in a murine prostate cancer model. All drugs were effective in impeding tumor growth but the mechanisms of action varied. Paclitaxel inhibited bcl-2 expression suggesting an apoptotic mechanism. Bropi... |
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Bropirimine as neoadjuvant therapy decreases residual disease and expression of markers PCNA and TGF-beta 1 in a rat orthotopic prostate adenocarcinoma.
Methods Find. Exp. Clin. Pharmacol. 19(4) , 261-7, (1997) The role of bropirimine in prostate cancer remains unexplored. To address the efficacy of this immune modulator as neoadjuvant therapy we utilized the orthotopic placement of the Dunning AT-3 tumor. 2.4-2.6 x 10(6) Dunning AT-3 cells were injected into the ve... |
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Complexation of the interferon inducer, bropirimine, with hydroxypropyl-beta-cyclodextrin.
Eur. J. Pharm. Sci. 9(4) , 381-6, (2000) Bropirimine (ABPP) is an orally active immunomodulator that increases endogenous alpha-interferon and other cytokines used clinically against carcinoma in situ of the bladder. The oral absorption of ABPP is poor because its low solubility in water. The purpos... |
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Pharmacology of the biological response modifier bropirimine (PNU-54461) on experimental autoimmune encephalomyelitis (EAE) in mice.
Int. J. Immunopharmacol. 21(6) , 391-409, (1999) In murine severe experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis (MS), we tested the efficacy of a 5-halo-6-phenyl pyrimidinone compound, bropirimine (PNU-54461). We observed that the compound is activ... |
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Oral bropirimine immunotherapy of rodent prostate cancer.
Eur. Urol. 31 Suppl 1 , 5-9, (1997) Bropirimine is an oral immunostimulant found to have efficacy in human transitional cell carcinoma in situ following the initial discovery of its antitumor activity against the murine bladder cancer MBT-2. To determine if bropirimine might have activity in pr... |
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Human biotransformation of bropirimine. Characterization of the major bropirimine oxidative metabolites formed in vitro.
Drug Metab. Dispos. 26(10) , 1048-51, (1998) Bropirimine (2-amino-5-bromo-6-phenyl-4-pyrimidinone) is a member of a class of antineoplastic agents known as aryl pyrimidinones. In human liver microsomal incubations, bropirimine oxidative metabolism is characterized by the formation of three metabolites. ... |
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Assay of bropirimine in rat plasma by means of robotic solid-phase extraction and high-performance liquid chromatography.
J. Chromatogr. A. 762(1-2) , 243-9, (1997) A rapid and simple high-performance liquid chromatography (HPLC) method incorporating automated solid-phase extraction (SPE) is described for the determination of bropirimine, 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone, in plasma samples from various species... |