4'-氯地西泮
4'-氯地西泮结构式
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常用名 | 4'-氯地西泮 | 英文名 | 4'-Chlorodiazepam |
|---|---|---|---|---|
| CAS号 | 14439-61-3 | 分子量 | 319.18500 | |
| 密度 | 1.35g/cm3 | 沸点 | 517.1ºC at 760mmHg | |
| 分子式 | C16H12Cl2N2O | 熔点 | 160-163ºC | |
| MSDS | 中文版 美版 | 闪点 | 266.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.
J. Med. Chem. 49 , 5845-8, (2006) Cultured rat astrocytes and C6 rat glioma were used as a differential screen for a variety of 1,2,3,4-tetrahydroisoquinoline (THI) derivatives. Compound 1 [1-(biphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrochloride] selectively blocked the ... |
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Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.
Life Sci. 92(6-7) , 345-51, (2013) This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity.Gene expression analyses with microarray gene chip and/or quantitative PCR were pe... |
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Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.
Biochem. Pharmacol. 97 , 99-110, (2015) As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the development of anti-obese and anti-diabetic therapies. There is inc... |
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Effect of phosphamidon on cognition and oxidative stress and its modulation by ascorbic acid and 4'-chlorodiazepam in rats.
Pharmacol. Biochem. Behav. 103(3) , 637-42, (2013) Neurosteroids and micronutrient are known to possess neuromodulator and neuroprotective activities. The present study was designed to investigate the effect of 4'-chlorodiazepam (4CD) or ascorbic acid (Vit C) on phosphamidon (PM) induced modulation of cogniti... |
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Suppressive effect of diazepam on IFN-gamma production by human T cells.
Int. Immunopharmacol. 10 , 267-71, (2010) Many studies showed that benzodiazepines could modulate immune responses through interaction with peripheral benzodiazepine receptors (PBRs) in immune cells but most of the studies were focused on monocytes and macrophages. In the present study, we revealed t... |
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Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.
Endocrinology 154(6) , 2156-65, (2013) Translocator protein (TSPO; 18 kDA) is a high-affinity cholesterol-binding protein that is integrally involved in cholesterol transfer from intracellular stores into mitochondria, the rate-determining step in steroid formation. Previous studies have shown tha... |
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Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats.
Eur. J. Pharmacol. 644(1-3) , 146-53, (2010) Oxidative stress plays a significant role in the pathogenesis of cardiac hypertrophy. Peripheral benzodiazepine receptors are ubiquitously expressed in various tissues, including the heart. Peripheral benzodiazepine receptors have been reported to be involved... |
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Reversal of propoxur-induced impairment of memory and oxidative stress by 4'-chlorodiazepam in rats.
Naunyn Schmiedebergs Arch. Pharmacol. 381(1) , 1-10, (2010) Carbamate pesticides like propoxur have been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present study was designed to explore the modulation of the effects of propoxur over cognitive function by proges... |
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Effects of peripheral benzodiazepine receptor ligand Ro5-4864 in four animal models of acute lung injury.
J. Surg. Res. 182(2) , 277-84, (2013) Acute lung injury (ALI) is a syndrome of inflammation and increased permeability of the blood-gas barrier. It is associated with high morbidity and mortality. Despite intensive research, treatments remain limited. The aim of the present study was to investiga... |
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4'-chlorodiazepam--agonist of peripheral benzodiazepine receptors as a protecting factor in IL-1 induced deregulation of collagen biosynthesis in cultured human chondrocytes.
Eur. J. Pharmacol. 647(1-3) , 31-6, (2010) Degenerative joint diseases are related to the excessive degradation of collagen and proteoglycans in cartilage. One of the potent inflammatory mediators of cartilage metabolism is interleukin-1 (IL-1) that has been implicated in the pathogenesis of degenerat... |