N-(+)-生物素基-4-氨基苯甲酸
N-(+)-生物素基-4-氨基苯甲酸结构式
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常用名 | N-(+)-生物素基-4-氨基苯甲酸 | 英文名 | 4-[5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoylamino]benzoic acid |
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| CAS号 | 6929-40-4 | 分子量 | 363.43100 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C17H21N3O4S | 熔点 | 295-297 °C | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Neonatal screening for biotinidase deficiency.
Ann. Clin. Lab. Sci. 22 , 144-154, (1992) Children with juvenile-onset multiple carboxylase deficiency lack biotinidase activity (biotinamide amidohydrolase, EC 3.5.1.12) in the liver and other tissues. Hence, little free biotin is metabolically available, resulting in seizures, acidosis, and serious... |
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Determination of biotinidase activity by liquid chromatography with fluorimetric detection.
J. Chromatogr. A. 383 , 148, (1986)
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Purification of biotinidase from human plasma and its activity on biotinyl peptides.
Biochemistry 24 , 2471, (1985) Biotinidase catalyzes the hydrolysis of N epsilon-biotinyllysine (biocytin) to form biotin and free lysine. The enzyme has been purified 4800-fold from outdated human plasma and was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to ha... |
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Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase.
J. Nutr. Biochem. 19 , 826-832, (2008) Posttranslational modification of histones by biotinylation can be catalyzed by both biotinidase (BTD) and holocarboxylase synthetase. Biotinylation of histones is an important epigenetic mechanism to regulate gene expression, DNA repair, and chromatin remode... |