5,5＇二硫代双(2-硝基苯甲酸)(DTNB)结构式
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常用名 | 5,5＇二硫代双(2-硝基苯甲酸)(DTNB) | 英文名 | DTNB |
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| CAS号 | 69-78-3 | 分子量 | 396.352 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | 671.9±55.0 °C at 760 mmHg | |
| 分子式 | C14H8N2O8S2 | 熔点 | 240-245 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 360.1±31.5 °C |
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Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments.
Food Chem. Toxicol. 71 , 97-105, (2014) The aim of this study was to explore the oxidative properties of ochratoxin A (OTA) and citrinin (CTN) as a possible underlying mechanism of their individual and/or combined cytotoxicity. Metabolic activity of PK15 porcine kidney cells was significantly reduc... |
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Metabolic and tissue-specific regulation of acyl-CoA metabolism.
PLoS ONE 10(3) , e0116587, (2015) Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases (ACS). Conversely, acyl-CoAs can be hydrolyzed by a family of acyl-CoA thioes... |
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Mitochondrial NADP(+)-dependent isocitrate dehydrogenase knockdown inhibits tumorigenicity of melanoma cells.
Biochem. Biophys. Res. Commun. 451(2) , 246-51, (2014) The potent cytotoxicity of reactive oxygen species (ROS) can cause various diseases but may also serve as a powerful weapon capable of destroying cancer cells. Although the balance between generation and elimination of ROS is maintained by the proper function... |
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Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.
Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014) Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nigerloxin, a fungal metabolite and a potent aldose reductase i... |
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The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.
J. Ethnopharmacol. 168 , 268-78, (2015) Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced ex... |
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The combined effect of furosemide and propranolol on GSH homeostasis in ACHN renal cells.
Toxicol. Mech. Methods 24(6) , 412-6, (2014) Propranolol, a beta-adrenergic blocker, is used in the treatment of a large number of cardiovascular diseases such as hypertension and arrhythmias. Propranolol, in combination with furosemide, is used to treat hypertensive disorders although their side effect... |
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Biotransformation and nitroglycerin-induced effects on antioxidative defense system in rat erythrocytes and reticulocytes.
Gen. Physiol. Biophys. 33(4) , 393-401, (2014) The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by liberated nitric oxide (NO) and formed reactive nitrogen species, which induces oxidative stress during biotransformation in red blood cells (RBCs). The aim of this study was to evaluate... |
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Oxidative damage of rat liver mitochondria during exposure to t-butyl hydroperoxide. Role of Ca²⁺ ions in oxidative processes.
Life Sci. 92(23) , 1110-7, (2013) The present study was designed for further evaluation of the biochemical mechanism of hepatic mitochondrial dysfunction under oxidative damages induced by organic hydroperoxide, tert-butyl hydroperoxide (tBHP), for estimation of the molecular targets impaired... |
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Pd-Ir Core-Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic.
ACS Nano 9 , 9994-10004, (2015) Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have been actively developed recently, limited progress has been ... |
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Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: a comparative study.
Life Sci. 122 , 42-50, (2015) Amaryllidaceae alkaloids exhibit a wide range of physiological effects, of which the acetylcholinesterase (AChE) inhibitory activity is the most relevant. However, scientific evidence related to their neuroprotective effectiveness against glutamate-induced to... |