多潘立酮
多潘立酮结构式
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常用名 | 多潘立酮 | 英文名 | Domperidone |
|---|---|---|---|---|
| CAS号 | 57808-66-9 | 分子量 | 425.911 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 723.6±70.0 °C at 760 mmHg | |
| 分子式 | C22H24ClN5O2 | 熔点 | 242.5ºC | |
| MSDS | 中文版 美版 | 闪点 | 391.4±35.7 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
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Evidence for the involvement of dopamine in stress-induced suppression of reproduction in the cichlid fish Oreochromis mossambicus.
J. Neuroendocrinol. 27(5) , 343-56, (2015) In the present study, we examined whether stress-induced suppression of reproduction is mediated through the catecholaminergic neurotransmitter dopamine (DA) in the female cichlid fish Oreochromis mossambicus. In the first experiment, application of antibody ... |
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Gold nanoparticles decorated poly-melamine modified glassy carbon sensor for the voltammetric estimation of domperidone in pharmaceuticals and biological fluids.
Talanta 141 , 53-9, (2015) The electrochemical response of an unmodified glassy carbon (GCE), poly-melamine/GCE and gold nanoparticle (AuNP)/poly-melamine/GCE is compared in the present protocol for the sensitive and selective determination of domperidone (DOM). The AuNPs were synthesi... |
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Domperidone interacts with pioglitazone but not with ondansetron via common CYP metabolism in vitro.
Xenobiotica 44(9) , 792-803, (2014) Domperidone (prokinetic agent) is frequently co-administered with pioglitazone (anitidiabetic) or ondansetron (antiemetic) in gastroparesis management. These drugs are metabolized via cytochome P-450 (CYP) 3A4, raising the possibility of interaction and adver... |
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Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.
Anal. Bioanal. Chem 406(25) , 6179-88, (2014) Over the past decades, several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier. So far, in high-performance liquid chromatography, most attention has been paid to micellar liquid chromatography an... |
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Effect of piperine, a major component of black pepper, on the pharmacokinetics of domperidone in rats.
J. Physiol. Pharmacol. 65(6) , 785-9, (2015) The present study was aimed to investigate the effect of piperine, a major active ingredient of black pepper, on the pharmacokinetics of domperidone in rats. Animals were given oral (p.o.) or intraperitoneal (i.p.) domperidone (20 mg/kg) alone or together wit... |
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Clinical challenge. Esophageal hiatal hernia.
J. Zoo Wildl. Med. 45(4) , 999-1001, (2014)
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The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis.
Am. J. Gastroenterol. 108(9) , 1382-91, (2013) The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI a... |
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Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion.
J. Mol. Biol. 425(4) , 755-66, (2013) Our laboratory has reported earlier that in leukocytes, phospholipase D2 (PLD2) is under control of Janus kinase 3 (JAK3), which mediates chemotaxis. Investigating JAK3 in cancer cells led to an important discovery as exponentially growing MDA-MB-231 human br... |
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A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.
Mol. Cell. Endocrinol. 366(1) , 31-7, (2013) The mineralocorticoid aldosterone plays an important role in regulating blood pressure, with excess causing hypertension and exacerbating cardiovascular disease. Previous studies have indicated a role for both phospholipase D (PLD) and protein kinase D (PKD) ... |
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[Domperidone, diclofenac: the time has come for drug alerts].
Rev. Med. Suisse 9(382) , 852-3, (2013)
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