5,6-二羟基-2-噻吩-2-基-嘧啶-4-羧酸甲酯结构式
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常用名 | 5,6-二羟基-2-噻吩-2-基-嘧啶-4-羧酸甲酯 | 英文名 | 5,6-DIHYDROXY-2-THIOPHEN-2-YL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER |
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| CAS号 | 391680-92-5 | 分子量 | 252.24700 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C10H8N2O4S | 熔点 | N/A | |
| MSDS | N/A | 闪点 | N/A |
5,6-二羟基-2-噻吩-2-基-嘧啶-4-羧酸甲酯用途pUL89核酸内切酶-IN-1(化合物13d)是人巨细胞病毒(HCMV)pUL89内切酶的有效抑制剂,IC50值为0.88μM,具有抗病毒活性[1]。 |
| 中文名 | 5,6-二羟基-2-噻吩-2-基-嘧啶-4-羧酸甲酯 |
|---|---|
| 英文名 | methyl 5-hydroxy-4-oxo-2-thiophen-2-yl-1H-pyrimidine-6-carboxylate |
| 英文别名 | 更多 |
| 描述 | pUL89核酸内切酶-IN-1(化合物13d)是人巨细胞病毒(HCMV)pUL89内切酶的有效抑制剂,IC50值为0.88μM,具有抗病毒活性[1]。 |
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| 相关类别 | |
| 靶点 |
IC50:0.88μM (pUL89-C) |
| 体外研究 | pUL89内切酶-IN-1(化合物13d)被强烈抑制pUL89-C,其值为IC500.88μM。pUL89核酸内切酶-IN-1在体外ADME中表现出极好的水溶性、血浆稳定性和代谢稳定性。pUL89核酸内切酶-IN-1在PAMPA中显示适度的通透性[1]。细胞毒性试验[1]细胞系：HFF细胞浓度：5μM孵育时间：168小时结果：在5μM时对HCMV有显著抑制作用。 |
| 参考文献 |
| 分子式 | C10H8N2O4S |
|---|---|
| 分子量 | 252.24700 |
| 精确质量 | 252.02000 |
| PSA | 120.52000 |
| LogP | 0.99060 |
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5,6-二羟基-2-噻吩-2-... 391680-92-5 |
| 文献：Pace, Paola; Di Francesco, M. Emilia; Gardelli, Cristina; Harper, Steven; Muraglia, Ester; Nizi, Emanuela; Orvieto, Federica; Petrocchi, Alessia; Poma, Marco; Rowley, Michael; Scarpelli, Rita; Laufer, Ralph; Paz, Odalys Gonzalez; Monteagudo, Edith; Bonelli, Fabio; Hazuda, Daria; Stillmock, Kara A.; Summa, Vincenzo Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2225 - 2239 |
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~%
5,6-二羟基-2-噻吩-2-... 391680-92-5 |
| 文献：Koch, Uwe; Attenni, Barbara; Malancona, Savina; Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Harper, Steven; Pacini, Barbara; Giomini, Claudia; Thomas, Steven; Incitti, Ilario; Tomei, Licia; De Francesco, Raffaele; Altamura, Sergio; Matassa, Victor G.; Narjes, Frank Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1693 - 1705 |
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~%
5,6-二羟基-2-噻吩-2-... 391680-92-5 |
| 文献：Koch, Uwe; Attenni, Barbara; Malancona, Savina; Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Harper, Steven; Pacini, Barbara; Giomini, Claudia; Thomas, Steven; Incitti, Ilario; Tomei, Licia; De Francesco, Raffaele; Altamura, Sergio; Matassa, Victor G.; Narjes, Frank Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1693 - 1705 |
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~14%
5,6-二羟基-2-噻吩-2-... 391680-92-5 |
| 文献：Summa, Vincenzo; Petrocchi, Alessia; Matassa, Victor G.; Gardelli, Cristina; Muraglia, Ester; Rowley, Michael; Paz, Odalys Gonzalez; Laufer, Ralph; Monteagudo, Edith; Pace, Paola Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6646 - 6649 |
| 5,6-二羟基-2-噻吩-2-基-嘧啶-4-羧酸甲酯上游产品 4 | |
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| 5,6-二羟基-2-噻吩-2-基-嘧啶-4-羧酸甲酯下游产品 2 | |
| 5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester |
| methyl 5,6-dihydroxy-2-thien-2-ylpyrimidine-4-carboxylate |
| 4-Pyrimidinecarboxylic acid,5,6-dihydroxy-2-(2-thienyl)-,methyl ester |
| methyl 2-(2-thienyl)-4,5-dihydroxypyrimidine-6-carboxylate |
| (6E)-6-[hydroxy(methoxy)methylidene]-2-thiophen-2-yl-1H-pyrimidine-4,5-dione |
CAS号849475-71-4
CAS号391680-79-8