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盐酸苄辛胺

盐酸苄辛胺用途

Benzoctamine hydrochloride (Ba-30803) 是一种具有抗焦虑作用的精神活性药物。Benzoctamine hydrochloride阻断中枢突触后 5-羟色胺受体,并可降低脑内5-HT的周转。

盐酸苄辛胺名称

[ CAS 号 ]:
10085-81-1

[ 中文名 ]:
盐酸苯佐卡因

[ 英文名 ]:
Benzoctamine Hydrochloride

[英文别名 ]:

Benzoctamine HCl
Tacitin
Tacitine
EINECS 233-216-0
BA 30,803

盐酸苄辛胺生物活性

[ 描述 ]:

Benzoctamine hydrochloride (Ba-30803) 是一种具有抗焦虑作用的精神活性药物。Benzoctamine hydrochloride阻断中枢突触后 5-羟色胺受体,并可降低脑内5-HT的周转。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[体内研究]

苯并辛胺盐酸盐(Ba-30803)抑制L-5-羟色胺(5-HTP)诱导的小鼠头部抽搐反应和5-甲氧基色胺(5-MT)预处理的大鼠头部抽搐反应。苯并辛胺也能拮抗色胺(TRP)诱导的大鼠前爪阵挛性惊厥[2]。

[参考文献]

[1]. Lippmann W, et al. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974;51(4):571-575.

[2]. Przegaliński E, et al. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978;30(6):781-790.

盐酸苄辛胺物理化学性质

[ 沸点 ]:
372ºC at 760mmHg

[ 分子式 ]:
C₁₈H₂₀ClN

[ 分子量 ]:
285.81100

[ 闪点 ]:
181.1ºC

[ 精确质量 ]:
285.12800

[ PSA ]:
12.03000

[ LogP ]:
4.62410

[ 蒸汽压 ]:
9.91E-06mmHg at 25°C

[ 储存条件 ]:
通风低温干燥

盐酸苄辛胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ4550000

CHEMICAL NAME :: 9,10-Ethanoanthracene-9-(10H)-methylamine, N-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 10085-81-1

LAST UPDATED :: 199506

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H19-N.Cl-H

MOLECULAR WEIGHT :: 285.84

WISWESSER LINE NOTATION :: L6 H666/GP 2AF P&&TTJ G1M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,336,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 51 mg/kg

SEX/DURATION :: female 2-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927- Volume(issue)/page/year: 49,1309,1973