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Temgicoluril

Temgicoluril用途

四甲基甘油(四甲基甘脲)是一种作用于GABA受体的小分子,具有抗焦虑活性[1]。

Temgicoluril名称

[ CAS 号 ]:
10095-06-4

[ 英文名 ]:
Temgicoluril

[英文别名 ]:

mebikar
Mebicar
2,4,6,8-tetramethylglycoluril
Temgicoluril

Temgicoluril生物活性

[ 描述 ]:

四甲基甘油(四甲基甘脲)是一种作用于GABA受体的小分子,具有抗焦虑活性[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[参考文献]

[1]. Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennosteĭ spektra psikhotropnogo deĭstviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89(5):568-70. Russian.

Temgicoluril物理化学性质

[ 密度 ]:
1.237g/cm3

[ 沸点 ]:
362.2ºC at 760 mmHg

[ 分子式 ]:
C₈H₁₄N₄O₂

[ 分子量 ]:
198.22

[ 闪点 ]:
171.9ºC

[ 精确质量 ]:
198.11200

[ PSA ]:
47.10000

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
1.96E-05mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
2-8°C，密封，避光

Temgicoluril毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI2938600

CHEMICAL NAME :: Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl-

CAS REGISTRY NUMBER :: 10095-06-4

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H14-N4-O2

MOLECULAR WEIGHT :: 198.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #3306128

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #3306128

Temgicoluril安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933990090

Temgicoluril合成路线

详细合成路线

Temgicoluril上下游产品

Temgicoluril上游产品

Temgicoluril下游产品

Temgicoluril海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%