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氯苯胺灵

氯苯胺灵用途

氯丙胺是一种氨基甲酸酯类除草剂和植物生长调节剂。氯丙胺通过干扰纺锤微管的组织来抑制有丝分裂和细胞分裂[1][2]。

氯苯胺灵名称

[ CAS 号 ]:
101-21-3

[ 中文名 ]:
氯苯胺灵

[ 英文名 ]:
Chlorpropham

[中文别名 ]:

[英文别名 ]:

Chlorpropham
chlor-IPC
1-methylethyl (3-chlorophenyl)carbamate
MFCD00037108
isopropyl 3-chlorocarbanilate
propan-2-yl (3-chlorophenyl)carbamate
propan-2-yl N-(3-chlorophenyl)carbamate
EINECS 202-925-7
Isopropyl m-chlorocarbanilate
Bud Nip

氯苯胺灵生物活性

[ 描述 ]:

氯丙胺是一种氨基甲酸酯类除草剂和植物生长调节剂。氯丙胺通过干扰纺锤微管的组织来抑制有丝分裂和细胞分裂[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氯丙胺(1-20μM；6 d)抑制盐藻培养物的细胞分裂[2]。氯丙嗪(10或20μM；6 d)在红色LED灯下显示盐藻培养物中的植物素增加[2]。

氯苯胺灵物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
251.1±23.0 °C at 760 mmHg

[ 熔点 ]:
41°C

[ 分子式 ]:
C₁₀H₁₂ClNO₂

[ 分子量 ]:
213.661

[ 闪点 ]:
105.7±22.6 °C

[ 精确质量 ]:
213.055649

[ PSA ]:
38.33000

[ LogP ]:
3.49

[ 外观性状 ]:
米色至棕色固体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
低于100℃下稳定,在酸、碱介质中缓慢水解

[ 水溶解性 ]:
0.009 g/100 ml very poor

氯苯胺灵MSDS

氯苯胺灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD8050000

CHEMICAL NAME :: Carbanilic acid, m-chloro-, isopropyl ester

CAS REGISTRY NUMBER :: 101-21-3

BEILSTEIN REFERENCE NO. :: 2211397

LAST UPDATED :: 199712

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C10-H12-Cl-N-O2

MOLECULAR WEIGHT :: 213.68

WISWESSER LINE NOTATION :: GR CMVOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 gm/kg/2Y-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68250 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 9 gm/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 2500 ug/L

REFERENCE :: PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,638,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,55,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,55,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3 JAN 1993

氯苯胺灵安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H351-H373-H411

[ 警示性声明 ]:
P273-P301 + P312 + P330-P391-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;F: Flammable;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S61-S36/37-S26

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
FD8050000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2924299035

氯苯胺灵合成路线

氯苯胺灵上下游产品

氯苯胺灵上游产品

氯苯胺灵下游产品

氯苯胺灵制备

1.氯苯胺灵可由3-氯苯基异氰酸酯与异丙醇作用制得。或由3-氯苯胺与氯甲酸异丙酯作用制得。

2.由3-氯苯基异氰酸酯与异丙醇作用制得氯苯胺灵。或由3-氯苯胺与氯甲酸异丙酯在氢氧化钠存在下制得.

3.既是植物生长调节剂又是除草剂。具有抑制β-淀粉酶活性，抑制植物RNA、蛋白质的合成，干扰氧化磷酸化和光合作用，破坏细胞分裂，因而能显著地抑制马铃薯贮存时的发芽力。也可用于果树的疏花、疏果。同时氯苯胺灵是一种高度选择性苗前或苗后早期除草剂，药剂被禾本科杂草芽鞘吸收，以植物的根部吸收为主，也可被叶片吸收，在体内向上、向下双向传导，能有效防除小麦、玉米、苜蓿、向日葵、马铃薯、甜菜、大豆、水稻、菜豆、胡萝卜、菠菜、莴苣、洋葱、辣椒等作物地中一年生禾本科杂草和部分阔叶草。

氯苯胺灵海关

[ 海关编码 ]: 2924299035

[ 中文概述 ]:
2924299035 甲基杀草隆、枯莠隆、邻酰胺等〔包括绿麦隆、氯苯胺灵、麦草氟甲酯、麦草氟异丙酯〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2924299035 2-chlorobenzaldehyde。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

氯苯胺灵文献

[Survey of pesticide residues in imported frozen vegetables and fruits (1989.4~2008.3)].

Shokuhin Eiseigaku Zasshi 52(2) , 121-9, (2011)

A survey of pesticide residues in 595 imported frozen products on the Tokyo market from April 1989 to March 2008 was carried out. Forty three kinds of pesticides, including organophosphorus, organochl...

Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors

Bioorg. Med. Chem. Lett. 19 , 6793-6, (2009)

The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and keto...

The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state.

Plant Mol. Biol. 73(1-2) , 181-9, (2010)

Chlorpropham (CIPC) and 1,4-dimethylnapthalene (DMN) are used to control postharvest sprouting of potato tubers. CIPC alters microtubule structure and function resulting in inhibition of cell division...

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