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草乌甲素

草乌甲素用途

草乌甲素(Bulleyaconitine A)是一种从乌头属植物分离出都具有镇痛和抗炎活性化合物。

草乌甲素名称

[ CAS 号 ]:
107668-79-1

[ 中文名 ]:
草乌甲素

[ 英文名 ]:
Bulleyaconitine A

[英文别名 ]:

BULLEYACONITINE A(RG)
BulleyaconicineA
BULLEYACONITINE A(P)

草乌甲素生物活性

[ 描述 ]:

草乌甲素(Bulleyaconitine A)是一种从乌头属植物分离出都具有镇痛和抗炎活性化合物。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

天然产物 >> 生物碱

研究领域 >> 神经疾病

[参考文献]

[1]. Wang CF, et al. Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg. 2008 Oct;107(4):1397-405.

[2]. Wang CF, et al. Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Anesthesiology. 2007 Jul;107(1):82-90.

[3]. Weng WY, et al. A pharmacokinetic study of intramuscular administration of bulleyaconitine A in healthy volunteers. Biol Pharm Bull. 2005 Apr;28(4):747-9.

[相关活性小分子]

草乌甲素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
690.9±55.0 °C at 760 mmHg

[ 分子式 ]:
C₃₅H₄₉NO₉

[ 分子量 ]:
627.765

[ 闪点 ]:
371.7±31.5 °C

[ 精确质量 ]:
627.340759

[ PSA ]:
112.99000

[ LogP ]:
1.05

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.590

[ 储存条件 ]:
室温

草乌甲素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4932000

CHEMICAL NAME :: Methanone, ((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20- ethyl-13-hydroxy-1,6, 16- trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxy phenyl)-

CAS REGISTRY NUMBER :: 107668-79-1

LAST UPDATED :: 199503

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C35-H49-N-O9

MOLECULAR WEIGHT :: 627.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 510 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 28,378,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 28,378,1993

草乌甲素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H330

[ 警示性声明 ]:
P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN 1544PSN1 6.1 / PGII