107668-79-1

• 常用中文名：草乌甲素
• 常用英文名：Bulleyaconitine A
• CAS号：107668-79-1
• 分子式：C₃₅H₄₉NO₉
• 分子量：627.765
• 相关类别： 原料药 解热镇痛药 非甾抗炎药
• 发布时间：2018-05-14 08:00:00
• 更新时间：2024-01-09 11:44:51
• 草乌甲素(Bulleyaconitine A)是一种从乌头属植物分离出都具有镇痛和抗炎活性化合物。

名称

• 中文名: 草乌甲素
• 英文名: Bulleyaconitine A
• 英文别名: (1α,6α,7β,14α,16β)-20-Ethyl-13-hydroxy-1,6,16-trimethoxy-14-(4-methoxybenzoyl)-4-(methoxymethyl)aconitan-8-yl acetate; BULLEYACONITINE A: METHANONE,[(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL); BULLEYACONITINE A(RG); 16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-y-6; BulleyaconicineA; 20-Ethyl-13-hydroxy-1,6,16-trimethoxy-14-(4-methoxybenzoyl)-4-(methoxymethyl)aconitan-8-yl acetate; Methanone, [8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-; Methanone, [(1α,6α,7β,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-; BULLEYACONITINE A(P); METHANONE,[(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL); 20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 690.9±55.0 °C at 760 mmHg
• 分子式: C₃₅H₄₉NO₉
• 分子量: 627.765
• 闪点: 371.7±31.5 °C
• 精确质量: 627.340759
• PSA: 112.99000
• LogP: 1.05
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.590
• 储存条件: 室温

生物活性

• 描述: 草乌甲素(Bulleyaconitine A)是一种从乌头属植物分离出都具有镇痛和抗炎活性化合物。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  天然产物 >> 生物碱
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Wang CF, et al. Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg. 2008 Oct;107(4):1397-405.

  [2]. Wang CF, et al. Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Anesthesiology. 2007 Jul;107(1):82-90.

  [3]. Weng WY, et al. A pharmacokinetic study of intramuscular administration of bulleyaconitine A in healthy volunteers. Biol Pharm Bull. 2005 Apr;28(4):747-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : PC4932000 CHEMICAL NAME : Methanone, ((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20- ethyl-13-hydroxy-1,6, 16- trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxy phenyl)- CAS REGISTRY NUMBER : 107668-79-1 LAST UPDATED : 199503 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C35-H49-N-O9 MOLECULAR WEIGHT : 627.85 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 510 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 28,378,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 920 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 28,378,1993

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300 + H330
• 警示性声明: P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
• 危害码 (欧洲): Xi
• 危险品运输编码: UN 1544PSN1 6.1 / PGII