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亚老哥乐1254

亚老哥乐1254用途

阿草胺1254是一种多氯联苯(PCB)与联苯和54%氯的混合物。Aroclor 1254以剂量依赖的方式降低细胞活力并诱导细胞内活性氧的过量产生。阿草胺1254暴露可降低钙稳态、成骨细胞分化和骨形成[1]。

亚老哥乐1254名称

[ CAS 号 ]:
11097-69-1

[ 中文名 ]:
亚老哥乐1254

[ 英文名 ]:
PCB No 157(Aroclor 1254) solution

[英文别名 ]:

1,1'-Biphenyl, 2,3,3',4,4'-pentachloro-
2,3,3',4,4'-Pentachloro-1,1'-biphenyl
2,3,3',4,4'-Pentachlorobiphenyl

亚老哥乐1254生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[参考文献]

[1]. R D Kimbrough, et al. Morphological changes in livers of rats fed polychlorinated biphenyls: light microscopy and ultrastructure. Arch Environ Health. 1972 Nov;25(5):354-64.

亚老哥乐1254物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
392.2±37.0 °C at 760 mmHg

[ 熔点 ]:
95.86°C (estimate)

[ 分子式 ]:
C₁₂H₅Cl₅

[ 分子量 ]:
326.433

[ 闪点 ]:
193.6±23.9 °C

[ 精确质量 ]:
323.883392

[ LogP ]:
6.36

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.620

[ 储存条件 ]:
room temp

[ 稳定性 ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents. Attacks some forms of plastics and rubber.

亚老哥乐1254安全信息

[ 符号 ]:

GHS02, GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H304-H315-H336-H373-H410

[ 警示性声明 ]:
P210-P273-P301 + P310-P331-P370 + P378-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,Xn,N,T

[ 风险声明 (欧洲) ]:
11-38-50/53-65-67-33-62-51/53-48/20-36/37/38-22-39/23/24/25-23/24/25-40-37/38-20/21/22-45

[ 安全声明 (欧洲) ]:
9-16-29-33-60-61-62-35-36/37-36-26-45-7-23-53

[ 危险品运输编码 ]:
2315

[ RTECS号 ]:
TQ1360000

[ 包装等级 ]:
II

亚老哥乐1254文献

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Arch. Toxicol. 89 , 2413-27, (2015)

Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicatin...

Enormous PCBs increase in oysters from the coast of Guangdong, China

Mar. Pollut. Bull. 62(6) , 1333-6, (2011)

Highlights ► PCB concentrations (ngg−1 d.w.) ranged from 30 to 2040 with a mean of 315 in 2003–2007. ► Annual PCB levels were 313, 290, 342ngg−1 d.w., respectively in 2003, 2006, 2007. ► Recent PCB le...

Transcriptome-wide gene expression in a rat model of attention deficit hyperactivity disorder symptoms: rats developmentally exposed to polychlorinated biphenyls.

Am. J. Med. Genet. B. Neuropsychiatr. Genet. 156B(8) , 898-912, (2011)

Polychlorinated biphenyls (PCB) exposure in rodents provides a useful model for the symptoms of Attention deficit hyperactivity disorder (ADHD). The goal of this study is to identify genes whose expre...

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