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油酸乙酯

油酸乙酯用途

Ethyl oleate 是通过油酸和乙醇的缩合形成的脂肪酸酯。Ethyl oleate 是纳米结构脂质载体 (NLC) 中的液体脂质成分。 NLC 是可口服的反式阿魏酸 (TFA) 的给药载体。

油酸乙酯名称

[ CAS 号 ]:
111-62-6

[ 中文名 ]:
油酸乙酯

[ 英文名 ]:
Ethyl Oleate

[中文别名 ]:

[英文别名 ]:

ethylis oleas
MFCD00009579
ETHYLOLEATE,NF
EINECS 203-889-5
Ethylis oleas,Oleic acid ethyl ester
Oleic acid ethyl
oleic acid ethyl ester
Ethyloleat
oleic
Ethyl oleate

油酸乙酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Zhang Y, et al. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid ascompared with conventional solid lipid nanoparticles. Int J Pharm. 2016 Sep 10;511(1):57-64.

油酸乙酯物理化学性质

[ 密度 ]:
0.87 g/mL at 25 °C(lit.)

[ 沸点 ]:
216-218 °C15 mm Hg

[ 熔点 ]:
−32 °C(lit.)

[ 分子式 ]:
C₂₀H₃₈O₂

[ 分子量 ]:
310.514

[ 闪点 ]:
91.8±20.4 °C

[ 精确质量 ]:
310.287170

[ PSA ]:
26.30000

[ LogP ]:
8.69

[ 外观性状 ]:
透明淡黄色油性液体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.455

[ 储存条件 ]:
−20°C

油酸乙酯MSDS

油酸乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG3715000

CHEMICAL NAME :: 9-Octadecenoic acid (Z)-, ethyl ester

CAS REGISTRY NUMBER :: 111-62-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H38-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,683,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,683,1982

油酸乙酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
RG3715000

[ 海关编码 ]:
2916150000

油酸乙酯合成路线

油酸乙酯上下游产品

油酸乙酯上游产品

油酸乙酯下游产品

油酸乙酯制备

1.由油酸与乙醇酯化而得。将硫酸加入油酸的乙醇溶液中，加热回流10小时。冷却，用甲醇钠中和至pH8-9，用水洗至中性，加无水氯化钙干燥，过滤，得油酸乙酯。 2. 烟草：FC，18。

油酸乙酯海关

[ 海关编码 ]: 2916150000

[ 中文概述 ]:
2916150000 油酸、亚油酸或亚麻酸及其盐和酯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装, 碳18/16含量

[ Summary ]:
2916150000 oleic, linoleic or linolenic acids, their salts and esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

油酸乙酯文献

Fatty acid ethyl esters disrupt neonatal alveolar macrophage mitochondria and derange cellular functioning.

Alcohol. Clin. Exp. Res. 39(3) , 434-44, (2015)

Chronic alcohol exposure alters the function of alveolar macrophages (AM), impairing immune defenses in both adult and neonatal lungs. Fatty acid ethyl esters (FAEEs) are biological markers of prenata...

N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation.

Drug Deliv. 22 , 516-21, (2015)

The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified m...

Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity.

Int. J. Pharm. 487 , 148-56, (2015)

The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as mel...

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