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青霉素钾

青霉素钾用途

Penicillin G potassium是一速效青霉素家族抗生素。

青霉素钾名称

[ CAS 号 ]:
113-98-4

[ 中文名 ]:
青霉素钾

[ 英文名 ]:
Penicillin G potassium

[中文别名 ]:

[英文别名 ]:

Benzyl Penicillinate Potassium Salt
MFCD00036193
Benzylpenicillinic acid potassium salt
Forpen
Benzylpenicillin potassium
Tabilin
Hipercilina
Hyasorb
Penicillin G potassium
Benzylpenicillin Potassium Salt

青霉素钾生物活性

[ 描述 ]:

Penicillin G potassium是一速效青霉素家族抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Roussel AJ, et al. Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses. Am J Vet Res. 2003 Nov;64(11):1360-3.

[2]. Byra C, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6.

[相关活性小分子]

青霉素钾物理化学性质

[ 熔点 ]:
214-217 â„ƒ

[ 分子式 ]:
C₁₆H₁₇KN₂O₄S

[ 分子量 ]:
372.480

[ 精确质量 ]:
372.054596

[ PSA ]:
114.84000

[ 外观性状 ]:
白色到灰白色粉末

[ 折射率 ]:
294 ° (C=1， H2O)

[ 储存条件 ]:
2~8°C，易燃物区域

青霉素钾MSDS

青霉素钾毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH9700000

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6- (2-phenylacetamido)-, monopotassium salt

CAS REGISTRY NUMBER :: 113-98-4

LAST UPDATED :: 199707

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C16-H17-N2-O4-S.K

MOLECULAR WEIGHT :: 372.51

WISWESSER LINE NOTATION :: T45 ANV ESTJ CMV1R& F1 F1 GVQ &-KA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11250 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 243 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6257 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5848 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 382 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 374 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 303 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 312 mg/kg/14W-I

TOXIC EFFECTS :: Gastrointestinal - changes in pancreatic weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 200 mg/kg/8D

REFERENCE :: JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 112,348,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81952 No. of Facilities: 1261 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 3510 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81952 No. of Facilities: 504 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 27005 (estimated) No. of Female Employees: 20458 (estimated)

青霉素钾安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
42/43-34-11

[ 安全声明 (欧洲) ]:
36/37-45-36/37/39-26-16

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XH9700000

[ 海关编码 ]:
2941109900

青霉素钾合成路线

青霉素钾上下游产品

青霉素钾上游产品

青霉素钾下游产品

青霉素钾制备

由氯屈米通与顺丁烯二酸成盐而得。

青霉素钾海关

[ 海关编码 ]: 2941109900

青霉素钾文献

The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator.

Fungal Genet. Biol. 49(12) , 1004-13, (2012)

We described previously that an autoinducer molecule, identified as 1,3-diaminopropane (1,3-DAP), is secreted by Penicillium chrysogenum and Acremonium chrysogenum. Using pH-controlled fermentor cultu...

Chronic inflammatory demyelinating polyneuropathy associated with neurosyphilis.

Am. J. Med. Sci. 349(1) , 90-1, (2015)

[Clinical toxicology of mushroom poisoning. Amanita virosa].

Chudoku. Kenkyu. 26(3) , 210-4, (2013)

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