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3-氨基-2-(4-氯苯基)丙基膦酸

3-氨基-2-(4-氯苯基)丙基膦酸用途

法氯芬是一种选择性GABAB受体拮抗剂。法克罗芬是一种外周和中枢巴氯芬拮抗剂。Phaclofen可能是一种潜在的化合物,用于确定GABA和(-)-巴氯芬相互作用的中枢和外周荷包牡丹碱不敏感受体的生理意义[1][2]。

3-氨基-2-(4-氯苯基)丙基膦酸名称

[ CAS 号 ]:
114012-12-3

[ 中文名 ]:
法克罗芬

[ 英文名 ]:
PHACLOFEN

[中文别名 ]:

3-氨基-2-(4-氯苯基)丙基膦酸

[英文别名 ]:

3-Amino-2-(4-chlorophenyl)propanephosphonic acid
MFCD00069328

3-氨基-2-(4-氯苯基)丙基膦酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[ 靶点 ]

GABAB receptor[1]

[体内研究]

法氯芬(100 nmol；鞘内注射)拮抗巴氯芬的抑制作用。Phaclofen(100 nmol)对脊髓反射没有刺激或抑制作用[3]。

[参考文献]

[1]. Johnson CM, et al. The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release. Neuropharmacology. 2020;176:108214.

[2]. Kerr DI, et al. Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 1987;405(1):150-154.

[3]. Wüllner U, et al. Phaclofen antagonizes the depressant effect of baclofen on spinal reflex transmission in rats. Brain Res. 1989;496(1-2):341-344.

3-氨基-2-(4-氯苯基)丙基膦酸物理化学性质

[ 密度 ]:
1.432 g/cm3

[ 沸点 ]:
467.1ºC at 760 mmHg

[ 分子式 ]:
C₉H₁₃ClNO₃P

[ 分子量 ]:
249.63100

[ 闪点 ]:
236.3ºC

[ 精确质量 ]:
249.03200

[ PSA ]:
93.36000

[ LogP ]:
2.26030

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
室温

3-氨基-2-(4-氯苯基)丙基膦酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

3-氨基-2-(4-氯苯基)丙基膦酸合成路线

详细合成路线

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3-氨基-2-(4-氯苯基)丙基膦酸文献

PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.

J. Neurophysiol. 112(1) , 22-9, (2014)

Transmitter-mediated homosynaptic potentiation is generally implemented by the same transmitter that mediates the excitatory postsynaptic potentials (EPSPs), e.g., glutamate. When a presynaptic neuron...

Transcriptome analysis of the key role of GAT2 gene in the hyper-accumulation of copper in the oyster Crassostrea angulata.

Sci. Rep. 5 , 17751, (2015)

One paradigm of oysters as the hyper-accumulators of many toxic metals is the inter-individual variation of metals, but the molecular mechanisms remain very elusive. A comprehensive analysis of the tr...

The antinociceptive effect of stimulating the retrosplenial cortex in the rat tail-flick test but not in the formalin test involves the rostral anterior cingulate cortex.

Pharmacol. Biochem. Behav. 131 , 112-8, (2015)

The stimulation of the retrosplenial cortex (RSC) is antinociceptive in the rat tail-flick and formalin tests. The rat RSC is caudal to and send projections to the ipsilateral anterior cingulate corte...

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